ER-to-Lysosome Associated Degradation (ERLAD) in a Nutshell: mammalian, yeast and plant ER-phagy as induced by misfolded proteins.
Sign Up to like & getrecommendations! Published in 2023 at "FEBS letters"
DOI: 10.1002/1873-3468.14674
Abstract: Conserved catabolic pathways operate to remove aberrant polypeptides from the endoplasmic reticulum (ER), the major biosynthetic organelle of eukaryotic cells. The best known are the ER-associated degradation (ERAD) pathways that control retro-translocation of terminally misfolded… read more here.
Keywords: lysosome associated; associated degradation; mammalian yeast; misfolded proteins ... See more keywords
ER-to-lysosome-associated degradation acts as failsafe mechanism upon ERAD dysfunction
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DOI: 10.1038/s44319-024-00165-y
Abstract: The endoplasmic reticulum (ER) produces proteins destined to organelles of the endocytic and secretory pathways, the plasma membrane, and the extracellular space. While native proteins are transported to their intra- or extracellular site of activity,… read more here.
Keywords: associated degradation; erlad pathways; lysosome associated; erad dysfunction ... See more keywords
Danon Disease Presenting with Slowly Progressive Cardiomyopathy and Harboring a Novel Missense Variant in the Lysosome-associated Membrane Protein Type 2 (LAMP-2) Gene
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DOI: 10.2169/internalmedicine.3953-24
Abstract: Danon disease (DD) is a rare lysosomal storage disorder resulting from pathogenic variants of the lysosome-associated membrane protein type 2 (LAMP-2) gene. The disease is characterized by severe cardiomyopathy, which rapidly progresses to end-stage heart… read more here.
Keywords: disease; associated membrane; lysosome associated; danon disease ... See more keywords
Characteristic of molecular subtype based on lysosome-associated genes reveals clinical prognosis and immune infiltration of gastric cancer
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DOI: 10.3389/fonc.2023.1155418
Abstract: Background Lysosome are involved in nutrient sensing, cell signaling, cell death, immune responses and cell metabolism, which play an important role in the initiation and development of multiple tumors. However, the biological function of lysosome… read more here.
Keywords: lysosome associated; prognosis; associated genes; analysis ... See more keywords
The role and regulatory mechanism of lysosome associated protein transmembrane 4β in tumors
Sign Up to like & getrecommendations! Published in 2025 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2025.1552007
Abstract: The oncogene LAPTM4B (encoding lysosome-associated protein transmembrane-4β), first cloned in hepatocellular carcinoma cells, is located on chromosome 8q22.1 and encodes two isoforms, LAPTM4B-35 and LAPTM4B-24. LAPTM4B proteins have four transmembrane structural domains and are mainly… read more here.
Keywords: laptm4b; lysosome associated; role; protein transmembrane ... See more keywords