The Rhodococcus equi virulence protein VapA disrupts endolysosome function and stimulates lysosome biogenesis
Sign Up to like & getrecommendations! Published in 2017 at "MicrobiologyOpen"
DOI: 10.1002/mbo3.416
Abstract: Rhodococcus equi (R. equi) is an important pulmonary pathogen in foals that often leads to the death of the horse. The bacterium harbors a virulence plasmid that encodes numerous virulence‐associated proteins (Vaps) including VapA that… read more here.
Keywords: virulence; rhodococcus equi; lysosome biogenesis; function ... See more keywords
AMPK-Mediated Lysosome Biogenesis in Lung Cancer Growth.
Sign Up to like & getrecommendations! Published in 2019 at "Cell metabolism"
DOI: 10.1016/j.cmet.2018.12.011
Abstract: Cancer cells must adapt to metabolic stress during tumor progression. In this issue of Cell Metabolism, Eichner et al. (2019) report that lung cancer development in genetically engineered mice requires the energy sensor AMP-activated protein kinase… read more here.
Keywords: mediated lysosome; biogenesis lung; lung cancer; lysosome biogenesis ... See more keywords
Endocytic regulation of cellular ion homeostasis controls lysosome biogenesis
Sign Up to like & getrecommendations! Published in 2020 at "Nature Cell Biology"
DOI: 10.1038/s41556-020-0535-7
Abstract: Lysosomes serve as cellular degradation and signalling centres that coordinate metabolism in response to intracellular cues and extracellular signals. Lysosomal capacity is adapted to cellular needs by transcription factors, such as TFEB and TFE3, which… read more here.
Keywords: controls lysosome; ion homeostasis; lysosome biogenesis; biogenesis ... See more keywords
Lysosome biogenesis regulated by the amino-acid transporter SLC15A4 is critical for functional integrity of mast cells
Sign Up to like & getrecommendations! Published in 2017 at "International Immunology"
DOI: 10.1093/intimm/dxx063
Abstract: SLC15A4 regulates secretory-granule biogenesis in mast-cell lysosomes read more here.
Keywords: biogenesis regulated; amino acid; mast; regulated amino ... See more keywords
Covalent JNK inhibitor, JNK-IN-8, suppresses tumor growth in triple-negative breast cancer by activating TFEB and TFE3 mediated lysosome biogenesis and autophagy.
Sign Up to like & getrecommendations! Published in 2022 at "Molecular cancer therapeutics"
DOI: 10.1158/1535-7163.mct-21-1044
Abstract: The heterogeneity and aggressiveness of Triple-Negative Breast Cancer (TNBC) contribute to its early recurrence and metastasis. Despite substantial research to identify effective therapeutic targets, TNBC remains elusive in terms of improving patient outcomes. Here, we… read more here.
Keywords: biogenesis autophagy; lysosome biogenesis; jnk; tfeb tfe3 ... See more keywords
GSK3β-dependent lysosome biogenesis: An effective pathway to mitigate renal fibrosis with LM49
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.925489
Abstract: Renal fibrosis is an incurable disorder characterised by an imbalance of the extracellular matrix (ECM) favouring excess production over degradation. The identification of actionable pathways and agents that promote ECM degradation to restore ECM homeostasis… read more here.
Keywords: lysosome biogenesis; gsk3; renal fibrosis; lm49 ... See more keywords
Alcohol-Induced Lysosomal Damage and Suppression of Lysosome Biogenesis Contribute to Hepatotoxicity in HIV-Exposed Liver Cells
Sign Up to like & getrecommendations! Published in 2021 at "Biomolecules"
DOI: 10.3390/biom11101497
Abstract: Although the causes of hepatotoxicity among alcohol-abusing HIV patients are multifactorial, alcohol remains the least explored “second hit” for HIV-related hepatotoxicity. Here, we investigated whether metabolically derived acetaldehyde impairs lysosomes to enhance HIV-induced hepatotoxicity. We… read more here.
Keywords: hiv; alcohol induced; hepatotoxicity; lysosome biogenesis ... See more keywords