Impairment of Lysosome Function and Autophagy in Rare Neurodegenerative Diseases
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DOI: 10.1016/j.jmb.2020.02.033
Abstract: Rare genetic diseases affect a limited number of patients, but their etiology is often known, facilitating the development of reliable animal models and giving the opportunity to investigate physiopathology. Lysosomal storage disorders are a group… read more here.
Keywords: neurodegenerative diseases; alteration; lysosome function; autophagy ... See more keywords
Targeting lysosome function causes selective cytotoxicity in VHL-inactivated renal cell carcinomas.
Sign Up to like & getrecommendations! Published in 2019 at "Carcinogenesis"
DOI: 10.1093/carcin/bgz161
Abstract: The inactivation of the tumor suppressor gene, von Hippel-Lindau (VHL), has been identified as the earliest event in renal cell carcinoma (RCC) development. The loss of heterogeneity by chromosome 3p deletion followed by inactivating mutations… read more here.
Keywords: renal cell; vhl; lysosome function; targeting lysosome ... See more keywords