Selective Lysosome Membrane Turnover Is Induced by Nutrient Starvation.
Sign Up to like & getrecommendations! Published in 2020 at "Developmental cell"
DOI: 10.1016/j.devcel.2020.08.008
Abstract: Lysosome function is essential for cellular homeostasis, but quality-control mechanisms that maintain healthy lysosomes remain poorly characterized. Here, we developed a method to measure lysosome turnover and use this to identify a selective mechanism of… read more here.
Keywords: membrane turnover; turnover; lysosome membrane; lysosome ... See more keywords
Sphingosine kinase SPHK-1 maintains sphingolipid metabolism to protect lysosome membrane integrity in C. elegans.
Sign Up to like & getrecommendations! Published in 2025 at "Molecular biology of the cell"
DOI: 10.1091/mbc.e25-04-0182
Abstract: The maintenance of lysosome membrane integrity is vital for cell homeostasis and viability, but the underlying mechanisms are not well understood. In this study, we identified a novel role of SPHK-1, the sole C. elegans… read more here.
Keywords: membrane integrity; integrity; lysosome membrane; sphingosine kinase ... See more keywords
MYOF Reduces Lysosome Membrane Stress to Promote Pancreatic Cancer.
Sign Up to like & getrecommendations! Published in 2021 at "Cancer discovery"
DOI: 10.1158/2159-8290.cd-rw2021-041
Abstract: The membrane repair factor MYOF prevented lysosome membrane damage in pancreatic cancer cells. read more here.
Keywords: lysosome membrane; cancer; membrane; myof reduces ... See more keywords