Association study of genetic variation in the autophagy lysosome pathway genes and risk of eight kinds of cancers
Sign Up to like & getrecommendations! Published in 2018 at "International Journal of Cancer"
DOI: 10.1002/ijc.31288
Abstract: The autophagy lysosome pathway is essential to maintain cell viability and homeostasis in response to many stressful environments, which is reported to play a vital role in cancer development and therapy. However, the association of… read more here.
Keywords: kinds cancers; autophagy lysosome; lysosome pathway; cancer ... See more keywords
Inhibition of MEK5 suppresses TDP-43 toxicity via the mTOR-independent activation of the autophagy-lysosome pathway.
Sign Up to like & getrecommendations! Published in 2019 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2019.04.088
Abstract: The most prominent hallmarks of many neurodegenerative diseases are the accumulation of misfolded protein aggregates and the death of certain neuronal populations. Autophagy is the major intracellular mechanism that degrades protein aggregates and damaged cellular… read more here.
Keywords: mek5; mtor; lysosome pathway; autophagy lysosome ... See more keywords
AKT modulates the autophagy-lysosome pathway via TFEB
Sign Up to like & getrecommendations! Published in 2017 at "Cell Cycle"
DOI: 10.1080/15384101.2017.1337968
Abstract: The serine and threonine kinase AKT (also known as protein kinase B, PKB) integrates inputs from growth factors and metabolic effectors to control key multifunctional signaling hubs via direct phosphorylation of substrates that control cell… read more here.
Keywords: akt; activity; lysosome pathway; autophagy lysosome ... See more keywords
C9orf72 ALS-FTD: recent evidence for dysregulation of the autophagy-lysosome pathway at multiple levels.
Sign Up to like & getrecommendations! Published in 2021 at "Autophagy"
DOI: 10.1080/15548627.2021.1872189
Abstract: Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are two clinically distinct classes of neurodegenerative disorders. Yet, they share a range of genetic, cellular, and molecular features. Hexanucleotide repeat expansions (HREs) in the C9orf72 gene… read more here.
Keywords: kinase; repeat; c9orf72; als ftd ... See more keywords
Coronavirus Usurps the Autophagy-Lysosome Pathway and Induces Membranes Rearrangement for Infection and Pathogenesis
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Microbiology"
DOI: 10.3389/fmicb.2022.846543
Abstract: Autophagy is a crucial and conserved homeostatic mechanism for early defense against viral infections. Recent studies indicate that coronaviruses (CoVs) have evolved various strategies to evade the autophagy–lysosome pathway. In this minireview, we describe the… read more here.
Keywords: autophagy lysosome; membrane vesicles; double membrane; lysosome pathway ... See more keywords
Rab21 Protein Is Degraded by Both the Ubiquitin-Proteasome Pathway and the Autophagy-Lysosome Pathway
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23031131
Abstract: Rab21 is a GTPase protein that is functional in intracellular trafficking and involved in the pathologies of many diseases, such as Alzheimer’s disease (AD), glioma, cancer, etc. Our previous work has reported its interaction with… read more here.
Keywords: rab21 protein; autophagy lysosome; lysosome pathway; pathway ... See more keywords