Visualizing Autophagic Lysosome Reformation in Cells Using In Vitro Reconstitution Systems
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DOI: 10.1002/cpcb.44
Abstract: Autophagy is a lysosome‐based degradation pathway. Autophagic lysosome reformation (ALR) is a lysosomal membrane recycling process that marks the terminal step of autophagy. During ALR, LAMP1‐positive tubules, named reformation tubules, are extruded from autolysosomes, and… read more here.
Keywords: reformation; vitro reconstitution; lysosome reformation; autophagic lysosome ... See more keywords
Sequential conversion of PtdIns3P to PtdIns(3,5)P2 via endosome maturation couples nutrient signaling to lysosome reformation and basal autophagy
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DOI: 10.1080/15548627.2022.2124499
Abstract: ABSTRACT Macroautophagy/autophagy occurs basally under nutrient-rich conditions in most mammalian cells, contributing to protein and organelle quality control, and protection against aging and neurodegeneration. During autophagy, lysosomes are heavily utilized via their fusion with autophagosomes… read more here.
Keywords: ptdins3p; lysosome reformation; basal autophagy; kinase ... See more keywords