Lysosome‐Targeting Protein Degradation Through Endocytosis Pathway Triggered by Polyvalent Nano‐Chimera for AD Therapy
Sign Up to like & getrecommendations! Published in 2024 at "Advanced Materials"
DOI: 10.1002/adma.202411061
Abstract: The excessive up‐regulation of receptor for advanced glycation end products (RAGE), a well‐known pathological marker, drives the onset and progression of Alzheimer's disease. Although lysosome‐targeting protein degradation has emerged as an effective therapeutic modality, the… read more here.
Keywords: degradation; lysosome targeting; targeting protein; protein degradation ... See more keywords
Lysosome-Targeting Aggregation-Induced Emission Nanoparticle Enables Adoptive Macrophage Transfer-Based Precise Therapy of Bacterial Infections.
Sign Up to like & getrecommendations! Published in 2023 at "ACS nano"
DOI: 10.1021/acsnano.3c00796
Abstract: Traditional antibacterial procedures are getting inefficient due to the emergence of antimicrobial resistance, which makes alternative treatments in urgent demand. However, the selectivity toward infectious bacteria is still challenging. Herein, by taking advantage of the… read more here.
Keywords: lysosome targeting; ttd; therapy; macrophage transfer ... See more keywords
Intelligent Modular DNA Lysosome-Targeting Chimera Nanodevice for Precision Tumor Therapy.
Sign Up to like & getrecommendations! Published in 2024 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.4c10010
Abstract: Lysosome targeting chimeras (LYTACs) have emerged as a powerful modality that can eliminate traditionally undruggable extracellular tumor-related pathogenic proteins, but their low bioavailability and nonspecific distribution significantly restrict their efficacy in precision tumor therapy. Developing… read more here.
Keywords: therapy; lysosome targeting; precision; intelligent modular ... See more keywords
A co-assembly platform engaging macrophage scavenger receptor A for lysosome-targeting protein degradation
Sign Up to like & getrecommendations! Published in 2024 at "Nature Communications"
DOI: 10.1038/s41467-024-46130-0
Abstract: Targeted degradation of proteins has emerged as a powerful method for modulating protein homeostasis. Identification of suitable degraders is essential for achieving effective protein degradation. Here, we present a non-covalent degrader construction strategy, based on… read more here.
Keywords: scavenger receptor; protein degradation; degradation; lysosome targeting ... See more keywords
Lysosome-targeting luminescent lanthanide complexes: from molecular design to bioimaging.
Sign Up to like & getrecommendations! Published in 2022 at "Dalton transactions"
DOI: 10.1039/d2dt00128d
Abstract: Lysosomes are essential acidic cytoplasmic membrane-bound organelles in human cells that play a critical role in many cellular events. A comprehensive understanding of lysosome-specific imaging can ultimately help us to design robust organelle-targeting therapeutic reagents… read more here.
Keywords: luminescent lanthanide; lysosome targeting; design; targeting luminescent ... See more keywords
A Facile Fabrication of Lysosome-Targeting pH Fluorescent Nanosensor Based on PEGylated Polyester Block Copolymer
Sign Up to like & getrecommendations! Published in 2022 at "Polymers"
DOI: 10.3390/polym14122420
Abstract: A novel lysosome-targeting PEGylated polyester-based fluorescent pH nanosensor is fabricated by the combination of ring-opening copolymerization (ROCOP), side-group modification and subsequent self-assembly. First, a key target amphiphilic copolymer carrier for rhodamine (Rh) pH indicator is… read more here.
Keywords: copolymer; fluorescent nanosensor; lysosome targeting; fluorescent ... See more keywords