Lysyl Oxidase (LOX) Family Members: Rationale and Their Potential as Therapeutic Targets for Liver Fibrosis
Sign Up to like & getrecommendations! Published in 2020 at "Hepatology"
DOI: 10.1002/hep.31236
Abstract: The cross‐linking of structural extracellular matrix (ECM) components, especially fibrillar collagens and elastin, is strongly implicated in fibrosis progression and resistance to fibrosis reversal. Lysyl oxidase family members (LOX and LOXL1 [lysyl oxidase‐like 1], LOXL2… read more here.
Keywords: fibrosis; liver fibrosis; family members; family ... See more keywords
Measurement of lysyl oxidase activity from small tissue samples and cell cultures.
Sign Up to like & getrecommendations! Published in 2018 at "Methods in cell biology"
DOI: 10.1016/bs.mcb.2017.08.009
Abstract: Increasing interest in the multifunctional lysyl oxidase family of proteins is evident from the growth in the number of new publications each year. The enzymes have unique properties of strong affinities to extracellular matrix components,… read more here.
Keywords: tissue samples; samples cell; oxidase activity; lysyl oxidase ... See more keywords
Boosting collagen deposition with a lysyl oxidase/bone morphogenetic protein-1 cocktail.
Sign Up to like & getrecommendations! Published in 2020 at "Methods in cell biology"
DOI: 10.1016/bs.mcb.2019.10.011
Abstract: This book chapter describes the use of exogenous application of lysyl oxidase (LOX) and bone morphogenetic protein-1 (BMP1) to enhance collagen synthesis and deposition from fibroblasts in culture. The protocol includes the generation of human… read more here.
Keywords: collagen; morphogenetic protein; bone morphogenetic; lysyl oxidase ... See more keywords
The challenge of determining lysyl oxidase activity: Old methods and novel approaches.
Sign Up to like & getrecommendations! Published in 2021 at "Analytical biochemistry"
DOI: 10.1016/j.ab.2021.114508
Abstract: The lysyl oxidase (LOX) family of enzymes catalyze the oxidative deamination of lysine and hydroxylysine residues in collagen and elastin in the initiation step of the formation of covalent cross-linkages, an essential process for extracellular… read more here.
Keywords: challenge determining; oxidase activity; activity; lysyl oxidase ... See more keywords
Lysyl oxidase in cancer inhibition and metastasis.
Sign Up to like & getrecommendations! Published in 2018 at "Cancer letters"
DOI: 10.1016/j.canlet.2018.01.006
Abstract: Lysyl oxidase is an extracellular matrix, copper - dependent amine oxidase that catalyzes a key enzymatic step in the crosslinking of collagen and elastin. The enzyme is synthesized as a propeptide that is cleaved by… read more here.
Keywords: inhibition metastasis; lysyl oxidase; cancer; oxidase cancer ... See more keywords
Anti-metastatic Inhibitors of Lysyl Oxidase (LOX): Design and Structure–Activity Relationships
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Medicinal Chemistry"
DOI: 10.1021/acs.jmedchem.9b00335
Abstract: Lysyl oxidase (LOX) is a secreted copper-dependent amine oxidase that cross-links collagens and elastin in the extracellular matrix and is a critical mediator of tumor growth and metastatic spread. LOX is a target for cancer… read more here.
Keywords: chemistry; lox; lysyl oxidase; structure activity ... See more keywords
Recombinant Human Lysyl Oxidase-like 2 Secreted from Human Embryonic Kidney Cells Displays Complex and Acidic Glycans at All Three N-Linked Glycosylation Sites.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of proteome research"
DOI: 10.1021/acs.jproteome.7b00849
Abstract: Human lysyl oxidase-like 2 (hLOXL2), a glycoprotein implicated in tumor progression and organ fibrosis, is a molecular target for anticancer and antifibrosis treatment. This glycoprotein contains three predicted N-linked glycosylation sites; one is near the… read more here.
Keywords: protein; oxidase like; glycosylation; lysyl oxidase ... See more keywords
Lysyl oxidase‐like 2 inhibitor rescues D‐galactose‐induced skeletal muscle fibrosis
Sign Up to like & getrecommendations! Published in 2022 at "Aging Cell"
DOI: 10.1111/acel.13659
Abstract: Aging‐related sarcopenia is currently the most common sarcopenia. The main manifestations are skeletal muscle atrophy, replacement of muscle fibers with fat and fibrous tissue. Excessive fibrosis can impair muscle regeneration and function. Lysyl oxidase‐like 2… read more here.
Keywords: induced skeletal; muscle; inhibitor; lysyl oxidase ... See more keywords
Lysyl oxidase activity in human skin is increased by chronic ultraviolet radiation exposure and smoking
Sign Up to like & getrecommendations! Published in 2017 at "British Journal of Dermatology"
DOI: 10.1111/bjd.14959
Abstract: Lifestyle choices, such as tobacco smoking and sunbathing can lead to premature skin ageing1. These extrinsic accelerators of the ageing process cause profound changes to the abundance and arrangement of the elastic fibres and fibrillar… read more here.
Keywords: increased chronic; human skin; oxidase activity; lysyl oxidase ... See more keywords
High lysyl oxidase expression is an indicator of poor prognosis in dogs with cutaneous mast cell tumours.
Sign Up to like & getrecommendations! Published in 2023 at "Veterinary and comparative oncology"
DOI: 10.1111/vco.12898
Abstract: Mast cell tumour (MCT) is one of the most frequent skin tumours in dogs. Due to their unpredictable biological behaviour, MCTs often cause several therapeutic frustrations, leading to investigation regarding prognostic markers. Lysyl oxidase (LOX)… read more here.
Keywords: lox; lysyl oxidase; mast; expression ... See more keywords
Higher expression of lysyl oxidase family in GBM mesenchymal subtype and the clinical impact of LOXL3
Sign Up to like & getrecommendations! Published in 2018 at "Clinical Cancer Research"
DOI: 10.1158/1557-3265.tcm17-a77
Abstract: Lysyl oxidade (LOX) is involved in cell motility, cell signaling, and gene regulation. We have previously described LOX increased expression and activity in diffusely infiltrative astrocytomas (da Silva et al., 2015), corroborating the role of… read more here.
Keywords: higher expression; gbm; oxidase family; lysyl oxidase ... See more keywords