Lysyl Oxidases: Functions and Disorders.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Glaucoma"
DOI: 10.1097/ijg.0000000000000910
Abstract: Lysyl oxidases (LOX) are copper-dependent enzymes that oxidize lysyl and hydroxylysyl residues in collagen and elastin, as a first step in the stabilization of these extracellular matrix proteins through the formation of covalent cross-linkages, an… read more here.
Keywords: functions disorders; lysyl oxidases; oxidases functions;
Abstract B44: Lysyl oxidases suppress pancreatic cancer progression and inhibit FAK and ERK signaling
Sign Up to like & getrecommendations! Published in 2018 at "Cancer Research"
DOI: 10.1158/1538-7445.mousemodels17-b44
Abstract: Pancreatic cancer carries a dismal prognosis, as most patients present with locally advanced and metastatic disease at time of diagnosis. High levels of type I collagen extracellular matrix in pancreatic tumor specimens are associated with… read more here.
Keywords: collagen; lysyl oxidases; pancreatic cancer; cancer progression ... See more keywords
Role of lysyl oxidases in pathogenesis of pulmonary emphysema
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DOI: 10.1183/1393003.congress-2017.pa3930
Abstract: Introduction: Chronic obstructive pulmonary disease (COPD) includes pulmonary emphysema (PE), chronic bronchitis, certain types of bronchiectasis, and sometimes asthma. Abnormal elastic fiber polymerization and degradation are from characteristic properties of PE. The copper-dependent lysyl oxidases… read more here.
Keywords: lysyl oxidases; lox loxl1; pathogenesis; loxl1 loxl2 ... See more keywords
Fibrosis in Mesothelioma: Potential Role of Lysyl Oxidases
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DOI: 10.3390/cancers14040981
Abstract: Simple Summary Why do most drugs have limited effects in difficult-to-treat cancers such as mesothelioma? One explanation commonly given in response is that not enough drug can get into the tumor to generate an anti-tumor… read more here.
Keywords: tumor; mesothelioma; lysyl oxidases; role ... See more keywords
Lysyl Oxidases: Orchestrators of Cellular Behavior and ECM Remodeling and Homeostasis
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DOI: 10.3390/ijms231911378
Abstract: Lysyl oxidases have long been considered key secreted extracellular matrix modifying enzymes. As such, their activity has been associated with the crosslinking of collagens and elastin, and as a result, they have been linked to… read more here.
Keywords: ecm remodeling; oxidases orchestrators; behavior ecm; cellular behavior ... See more keywords