Lysyl-tRNA synthetase as a drug target in malaria and cryptosporidiosis
Sign Up to like & getrecommendations! Published in 2019 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.1814685116
Abstract: Significance Malaria and cryptosporidiosis are major burdens to both global health and economic development in many countries. Malaria caused >400,000 deaths in 2017, and cryptosporidiosis is estimated to cause >200,000 deaths a year. The spread… read more here.
Keywords: malaria cryptosporidiosis; drug; trna synthetase; lysyl trna ... See more keywords
Phosphomimetic S207D Lysyl–tRNA Synthetase Binds HIV-1 5′UTR in an Open Conformation and Increases RNA Dynamics
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DOI: 10.3390/v14071556
Abstract: Interactions between lysyl–tRNA synthetase (LysRS) and HIV-1 Gag facilitate selective packaging of the HIV-1 reverse transcription primer, tRNALys3. During HIV-1 infection, LysRS is phosphorylated at S207, released from a multi-aminoacyl–tRNA synthetase complex and packaged into… read more here.
Keywords: trna synthetase; phosphomimetic s207d; lysyl trna; synthetase ... See more keywords