KSHV RTA Induces Degradation of the Host Transcription Repressor ID2 To Promote the Viral Lytic Cycle
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Virology"
DOI: 10.1128/jvi.00101-22
Abstract: In addition to its transcription regulatory role, RTA is also known to have an E3 ubiquitin ligase activity, which RTA utilizes for inducing protein degradation. However, it is still largely unknown what host factors are… read more here.
Keywords: lytic cycle; kshv lytic; transcription; rta ... See more keywords
Caspase-Mediated Cleavage of the Transcription Factor Sp3: Possible Relevance to Cancer and the Lytic Cycle of Kaposi’s Sarcoma-Associated Herpesvirus
Sign Up to like & getrecommendations! Published in 2022 at "Microbiology Spectrum"
DOI: 10.1128/spectrum.01464-21
Abstract: The ORF50 protein of Kaposi’s sarcoma-associated herpesvirus (KSHV) is the key viral protein that controls the switch from latency to lytic reactivation. It is a potent transactivator that can activate target gene promoters via interacting… read more here.
Keywords: sarcoma associated; cleavage; kaposi sarcoma; lytic cycle ... See more keywords
Comparative ribosome profiling uncovers a dominant role for translational control in Toxoplasma gondii
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DOI: 10.1186/s12864-017-4362-6
Abstract: BackgroundThe lytic cycle of the protozoan parasite Toxoplasma gondii, which involves a brief sojourn in the extracellular space, is characterized by defined transcriptional profiles. For an obligate intracellular parasite that is shielded from the cytosolic… read more here.
Keywords: role; toxoplasma gondii; translational control; lytic cycle ... See more keywords
The Immunomodulatory Capacity of an Epstein-Barr Virus Abortive Lytic Cycle: Potential Contribution to Viral Tumorigenesis
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DOI: 10.3390/cancers10040098
Abstract: Epstein-Barr virus (EBV) is characterized by a bipartite life cycle in which latent and lytic stages are alternated. Latency is compatible with long-lasting persistency within the infected host, while lytic expression, preferentially found in oropharyngeal… read more here.
Keywords: epstein barr; cycle; barr virus; abortive lytic ... See more keywords
Immune Modulation by Epstein–Barr Virus Lytic Cycle: Relevance and Implication in Oncogenesis
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DOI: 10.3390/pathogens13100876
Abstract: EBV infects more than 90% of people globally, causing lifelong infection. The phases of the EBV life cycle encompass primary infection, latency, and subsequent reactivation or lytic phase. The primary infection usually happens without noticeable… read more here.
Keywords: virus; lytic phase; infection; oncogenesis ... See more keywords
Cytotoxic Drugs Activate KSHV Lytic Cycle in Latently Infected PEL Cells by Inducing a Moderate ROS Increase Controlled by HSF1, NRF2 and p62/SQSTM1
Sign Up to like & getrecommendations! Published in 2018 at "Viruses"
DOI: 10.3390/v11010008
Abstract: Previous studies have indicated that cytotoxic treatments may induce or not activate viral lytic cycle activation in cancer cells latently infected by Kaposi's sarcoma-associated herpesvirus (KSHV). To investigate the molecular mechanisms responsible for such an… read more here.
Keywords: p62 sqstm1; kshv lytic; p62; lytic cycle ... See more keywords
EZH2 Inhibition by DS3201 Triggers the Kaposi’s Sarcoma-Associated Herpesvirus Lytic Cycle and Potentiates the Effects Induced by SAHA in Primary Effusion Lymphoma Cells
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DOI: 10.3390/v16091490
Abstract: Primary Effusion Lymphoma (PEL) cells carry Kaposi’s sarcoma-associated herpesvirus (KSHV) in a latent state, except for a small number of cells in which the virus replicates to ensure its persistence into the infected host. However,… read more here.
Keywords: primary effusion; effusion lymphoma; kaposi sarcoma; lytic cycle ... See more keywords