Role of SUMOylation in Human Oncogenic Herpesvirus Infection.
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DOI: 10.1016/j.virusres.2020.197962
Abstract: Post-translational modification of target proteins by the Small Ubiquitin-like Modifier (SUMO) plays a critical role in regulation of many cellular processes including transcription, RNA processing, protein trafficking, DNA repair, and chromosome segregation, and is also… read more here.
Keywords: sumoylation; infection; human oncogenic; role ... See more keywords
Upregulation of ATF4-LAMP3 Axis by ORF45 Facilitates Lytic Replication of Kaposi’s Sarcoma-Associated Herpesvirus
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DOI: 10.1128/jvi.01456-22
Abstract: The lytic replication of Kaposi’s sarcoma-associated herpesvirus (KSHV) reprograms cellular transcription and translation to generate viral proteins and virion particles. Here, we show that the mediator of ER stress ATF4 and the expression of the… read more here.
Keywords: lytic replication; replication; lamp3; kaposi sarcoma ... See more keywords
FoxO1 Suppresses Kaposi’s Sarcoma-Associated Herpesvirus Lytic Replication and Controls Viral Latency
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DOI: 10.1128/jvi.01681-18
Abstract: Kaposi’s sarcoma-associated herpesvirus (KSHV) is associated with several cancers, including Kaposi’s sarcoma (KS). Both the KSHV latent and lytic replication phases are important for the development of KS. Identification of factors regulating the KSHV latent… read more here.
Keywords: kaposi sarcoma; foxo1; kshv latency; lytic replication ... See more keywords
Suppression of KSHV lytic replication and primary effusion lymphoma by selective RNF5 inhibition
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DOI: 10.1371/journal.ppat.1011103
Abstract: Primary effusion lymphoma (PEL), a rare aggressive B-cell lymphoma in immunosuppressed patients, is etiologically associated with oncogenic γ-herpesvirus infection. Chemotherapy is commonly used to treat PEL but usually results in poor prognosis and survival; thus,… read more here.
Keywords: inhibition; lytic replication; kshv lytic; effusion lymphoma ... See more keywords
Visualization of Marek’s Disease Virus Genomes in Living Cells during Lytic Replication and Latency
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DOI: 10.3390/v14020287
Abstract: Visualization of the herpesvirus genomes during lytic replication and latency is mainly achieved by fluorescence in situ hybridization (FISH). Unfortunately, this technique cannot be used for the real-time detection of viral genome in living cells.… read more here.
Keywords: replication latency; visualization; replication; lytic replication ... See more keywords
Design of a US28 ORF Deletion Virus in a Temperature-Sensitive Cytomegalovirus Strain Fails to Promote Lytic Replication in Hematopoietic Cells
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DOI: 10.3390/v14061280
Abstract: Human cytomegalovirus (CMV) is a ubiquitous pathogen that latently resides in hematopoietic cells. Latently infected individuals with dysfunctional immune systems often experience CMV reactivation, which can cause devastating disease and mortality. While factors dictating the… read more here.
Keywords: hematopoietic cells; lytic replication; temperature; virus ... See more keywords