Mutations in LZTR1 drive human disease by dysregulating RAS ubiquitination
Sign Up to like & getrecommendations! Published in 2018 at "Science"
DOI: 10.1126/science.aap7607
Abstract: Regulation of RAS by ubiquitination The protein LZTR1 is mutated in human cancers and developmental diseases. Work from two groups now converges to implicate the protein in regulating signaling by the small guanosine triphosphatase RAS.… read more here.
Keywords: mutations lztr1; disease; ras ubiquitination; human disease ... See more keywords
A Comprehensive Pan-Cancer Analysis of the Tumorigenic Effect of Leucine-Zipper-Like Transcription Regulator (LZTR1) in Human Cancer
Sign Up to like & getrecommendations! Published in 2022 at "Oxidative Medicine and Cellular Longevity"
DOI: 10.1155/2022/2663748
Abstract: The elucidation of the action site, mechanism of Leucine-Zipper-like Transcription Regulator-1 (LZTR1) and its relationship with RAS-MAPK signaling pathway attracts more and more scholars to focus on the researches of LZTR1 and its role in… read more here.
Keywords: lztr1 human; pan cancer; lztr1; leucine zipper ... See more keywords
Abstract A019: The role of KRAS ubiquitination in lung cancer heterogeneity
Sign Up to like & getrecommendations! Published in 2023 at "Molecular Cancer Research"
DOI: 10.1158/1557-3125.ras23-a019
Abstract: Lung cancer is the most frequent cancer with an aggressive clinical course and high mortality rates. About 30% of non-small lung cancer is driven by activating mutations in KRAS (Kirsten rat sarcoma virus). KRAS signaling… read more here.
Keywords: role kras; lung cancer; lztr1; kras ubiquitination ... See more keywords
Analysis of genes within the schizophrenia-linked 22q11.2 deletion identifies interaction of night owl/LZTR1 and NF1 in GABAergic sleep control
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DOI: 10.1371/journal.pgen.1008727
Abstract: The human 22q11.2 chromosomal deletion is one of the strongest identified genetic risk factors for schizophrenia. Although the deletion spans a number of known genes, the contribution of each of these to the 22q11.2 deletion… read more here.
Keywords: genes within; night; night owl; deletion ... See more keywords
Generation of a Mouse Model to Study the Noonan Syndrome Gene Lztr1 in the Telencephalon
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2021.673995
Abstract: The leucine zipper-like transcriptional regulator 1 (Lztr1) is a BTB-Kelch domain protein involved in RAS/MAPK pathway regulation. Mutations in LZTR1 are associated with cancers and Noonan syndrome, the most common RASopathy. The expression and function… read more here.
Keywords: noonan syndrome; model study; expression; telencephalon ... See more keywords
LZTR1: A promising adaptor of the CUL3 family
Sign Up to like & getrecommendations! Published in 2021 at "Oncology Letters"
DOI: 10.3892/ol.2021.12825
Abstract: The study of the disorders of ubiquitin-mediated proteasomal degradation may unravel the molecular basis of human diseases, such as cancer (prostate cancer, lung cancer and liver cancer, etc.) and nervous system disease (Parkinson's disease, Alzheimer's… read more here.
Keywords: promising adaptor; disease; lztr1 promising; cancer ... See more keywords