Hydroxamic Acid Inhibitors Provide Cross-Species Inhibition of Plasmodium M1 and M17 Aminopeptidases.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.8b01310
Abstract: There is an urgent clinical need for antimalarial compounds that target malaria caused by both Plasmodium falciparum and Plasmodium vivax. The M1 and M17 metalloexopeptidases play key roles in Plasmodium hemoglobin digestion and are validated… read more here.
Keywords: m17 aminopeptidases; hydroxamic acid; plasmodium; acid inhibitors ... See more keywords
Parasite metalo-aminopeptidases as targets in human infectious diseases.
Sign Up to like & getrecommendations! Published in 2023 at "Current drug targets"
DOI: 10.2174/1389450124666230224140724
Abstract: BACKGROUND Parasitic human infectious diseases are a worldwide health problem due to the increased resistance to conventional drugs. For this reason, the identification of novel molecular targets and the discovery of new chemotherapeutic agents are… read more here.
Keywords: inhibition; human infectious; m17 aminopeptidase; m17 ... See more keywords