Hydroxamic Acid Inhibitors Provide Cross-Species Inhibition of Plasmodium M1 and M17 Aminopeptidases.
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DOI: 10.1021/acs.jmedchem.8b01310
Abstract: There is an urgent clinical need for antimalarial compounds that target malaria caused by both Plasmodium falciparum and Plasmodium vivax. The M1 and M17 metalloexopeptidases play key roles in Plasmodium hemoglobin digestion and are validated… read more here.
Keywords: m17 aminopeptidases; hydroxamic acid; plasmodium; acid inhibitors ... See more keywords