ALKBH3‐Mediated M1A Demethylation of METTL3 Endows Pathological Fibrosis:Interplay Between M1A and M6A RNA Methylation
Sign Up to like & getrecommendations! Published in 2025 at "Advanced Science"
DOI: 10.1002/advs.202417067
Abstract: Epigenetic modifications serve as crucial molecular switches for pathological fibrosis; howbeit the role of m1A in this condition remains enigmatic. Herein, it is found that ALKBH3 exerts a pro‐fibrotic effect in pathological skin fibrosis by… read more here.
Keywords: methylation; mettl3; m1a; rna ... See more keywords
Effects of Epitranscriptomic RNA Modifications on the Catalytic Activity of the SARS‐CoV‐2 Replication Complex **
Sign Up to like & getrecommendations! Published in 2023 at "ChemBioChem"
DOI: 10.1002/cbic.202300095
Abstract: SARS‐CoV‐2 causes individualized symptoms. Many reasons have been given. We propose that an individual's epitranscriptomic system could be responsible as well. The viral RNA genome can be subject to epitranscriptomic modifications, which can be different… read more here.
Keywords: activity sars; replication; m1a; cov replication ... See more keywords
Transcriptome-Wide Mapping of N 1-Methyladenosine Methylome.
Sign Up to like & getrecommendations! Published in 2017 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-6807-7_16
Abstract: N 1-Methyladenosine (m1A) is a prevalent posttranscriptional RNA modification and commonly found in tRNA and rRNA. Very recent works have also demonstrated the prevalence of m1A in mammalian mRNA. Hence, high-throughput methods that allow transcriptome-wide… read more here.
Keywords: wide mapping; transcriptome wide; mapping methyladenosine; m1a ... See more keywords
Prokaryotic RNA N1-Methyladenosine Erasers Maintain tRNA m1A Modification Levels in Streptomyces venezuelae.
Sign Up to like & getrecommendations! Published in 2024 at "ACS chemical biology"
DOI: 10.1021/acschembio.4c00278
Abstract: tRNA modifications help maintain tRNA structure and facilitate translation and stress response. Found in all three kingdoms of life, m1A tRNA modification occurs in the T loop of many tRNAs, stabilizes tertiary tRNA structure, and… read more here.
Keywords: trna m1a; m1a; trna; maintain trna ... See more keywords
Cytoplasmic m1A reader YTHDF3 inhibits trophoblast invasion by downregulation of m1A-methylated IGF1R
Sign Up to like & getrecommendations! Published in 2020 at "Cell Discovery"
DOI: 10.1038/s41421-020-0144-4
Abstract: N1-methyladenosine (m1A) is one of the important post-transcriptional modifications in RNA and plays an important role in promoting translation or decay of m1A-methylated messenger RNA (mRNA), but the “reader” protein and the exact biological role… read more here.
Keywords: m1a; invasion; reader; ythdf3 ... See more keywords
ISGm1A: Integration of Sequence Features and Genomic Features to Improve the Prediction of Human m1A RNA Methylation Sites
Sign Up to like & getrecommendations! Published in 2020 at "IEEE Access"
DOI: 10.1109/access.2020.2991070
Abstract: As a new epitranscriptomic modification, N1-methyladenosine (m1A) plays an important role in the gene expression regulation. Although some computational methods were proposed to predict m1A modification sites, all of these methods apply machine learning predictions… read more here.
Keywords: sequence features; m1a rna; m1a; prediction ... See more keywords
m1A methylation modification patterns and metabolic characteristics in hepatocellular carcinoma
Sign Up to like & getrecommendations! Published in 2022 at "BMC Gastroenterology"
DOI: 10.1186/s12876-022-02160-w
Abstract: Background The dysregulation of RNA methylation has been demonstrated to contribute to tumorigenicity and progression in recent years. However, the alteration of N1-methyladenosine (m1A) methylation and its role in hepatocellular carcinoma (HCC) remain unclear. Methods… read more here.
Keywords: modification patterns; m1a methylation; metabolic characteristics; modification ... See more keywords
m1A within cytoplasmic mRNAs at single nucleotide resolution: a reconciled transcriptome-wide map.
Sign Up to like & getrecommendations! Published in 2018 at "RNA"
DOI: 10.1261/rna.067348.118
Abstract: Following synthesis, RNA can be modified with over 100 chemically distinct modifications. Recently, two studies-one by our group-developed conceptually similar approaches to globally map N1-methyladenosine (m1A) at single nucleotide resolution. Surprisingly, the studies diverged quite… read more here.
Keywords: m1a; within cytoplasmic; single nucleotide; nucleotide resolution ... See more keywords
Clinician’s Guide to Epitranscriptomics: An Example of N1-Methyladenosine (m1A) RNA Modification and Cancer
Sign Up to like & getrecommendations! Published in 2024 at "Life"
DOI: 10.3390/life14101230
Abstract: Epitranscriptomics is the study of modifications of RNA molecules by small molecular residues, such as the methyl (-CH3) group. These modifications are inheritable and reversible. A specific group of enzymes called “writers” introduces the change… read more here.
Keywords: epitranscriptomics example; m1a; methyladenosine m1a; clinician guide ... See more keywords