M2e‐specific antibodies protect against influenza PR8 virus in an isotype and route dependent manner
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Medical Virology"
DOI: 10.1002/jmv.28721
Abstract: The ectodomain of influenza matrix protein 2 (M2e) is a promising target for the development of universal prophylactic and therapeutic agents against influenza viruses of different subtypes. We constructed three M2e‐specific monoclonal antibody variants, M2A1‐1… read more here.
Keywords: protection; influenza pr8; m2e specific; m2e ... See more keywords
Improving Cross-Protection against Influenza Virus Using Recombinant Vaccinia Vaccine Expressing NP and M2 Ectodomain Tandem Repeats
Sign Up to like & getrecommendations! Published in 2019 at "Virologica Sinica"
DOI: 10.1007/s12250-019-00138-9
Abstract: Conventional influenza vaccines need to be designed and manufactured yearly. However, they occasionally provide poor protection owing to antigenic mismatch. Hence, there is an urgent need to develop universal vaccines against influenza virus. Using nucleoprotein… read more here.
Keywords: protection; m2e; recombinant vaccinia; influenza virus ... See more keywords
Reasonable permutation of M2e enhances the effect of universal influenza nanovaccine.
Sign Up to like & getrecommendations! Published in 2021 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2021.01.132
Abstract: Influenza A virus (IAV) occasionally cross-species transmission among humans, swine and avian. The ectodomain of matrix protein 2 (M2e) is highly conserved in IAV, and multi-copy M2e from different species are usually displayed on the… read more here.
Keywords: universal iav; m2e; permutation m2e; m2e enhances ... See more keywords
Cross protection by inactivated recombinant influenza viruses containing chimeric hemagglutinin conjugates with a conserved neuraminidase or M2 ectodomain epitope.
Sign Up to like & getrecommendations! Published in 2020 at "Virology"
DOI: 10.1016/j.virol.2020.08.003
Abstract: Influenza virus neuraminidase (NA) contains a universally conserved epitope (NAe, NA222-230). However, no studies have reported vaccines targeting this NA conserved epitope and inducing antibodies recognizing NAe. The extracellular domain of M2 (M2e) is considered… read more here.
Keywords: m2e; inactivated recombinant; recombinant influenza; epitope ... See more keywords
Hemisilicone Elastomers That Are Recyclable to the Monomer.
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DOI: 10.1021/acsmacrolett.2c00548
Abstract: Methyl-, vinyl-, and hydride-terminated polymers of the heterocyclic monomer, 2,2,5,5-tetramethyl-2,5-disila-1-oxacyclopentane (c-M2E) were prepared by sulfuric acid-catalyzed, ring-opening equilibration with the end-capping agents hexamethyldisiloxane (MM), divinyltetramethyldisiloxane (MVMV), and tetramethyldisiloxane (MHMH), respectively. The molecular weights of the… read more here.
Keywords: m2e; monomer; hemisilicone elastomers; end ... See more keywords
Oral immunization with an attenuated Salmonella Gallinarum encoding the H9N2 haemagglutinin and M2 ectodomain induces protective immune responses against H9N2 infection in chickens
Sign Up to like & getrecommendations! Published in 2020 at "Avian Pathology"
DOI: 10.1080/03079457.2020.1775782
Abstract: ABSTRACT H9N2, a low pathogenic avian influenza virus, causes significant economic losses in the poultry industry worldwide. Herein, we describe the construction of an attenuated Salmonella Gallinarum (SG) strain for expression and delivery of H9N2… read more here.
Keywords: m2e; salmonella; immune responses; ha1 ha2 ... See more keywords
Design, synthesis and primary immunologic evaluation of M2e-CRM197 conjugate as a universal influenza vaccine candidate.
Sign Up to like & getrecommendations! Published in 2020 at "Current pharmaceutical biotechnology"
DOI: 10.2174/1389201021666201104145006
Abstract: BACKGROUND Influenza is a contagious respiratory illness caused by acute infection of influenza viruses, among which influenza A virus causes epidemic seasonal infection nearly every year. Along with unpredictability of evolving influenza A virus and… read more here.
Keywords: m2e crm197; m2e; crm197 conjugate; crm197 ... See more keywords
Expression of Influenza M2e-NP Recombinant Fusion Protein in Escherichia coli BL21 (DE3) and Its Binding to Antibodies
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DOI: 10.3390/vaccines10122066
Abstract: The current influenza vaccines only confer protection against the circulating influenza subtypes, therefore universal vaccines are needed to prevent upcoming influenza outbreaks caused by emerging influenza subtypes. The extracellular domain of influenza A M2 protein… read more here.
Keywords: fusion; escherichia coli; influenza; m2e ... See more keywords
An Inactivated Influenza Virus Vaccine Approach to Targeting the Conserved Hemagglutinin Stalk and M2e Domains
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DOI: 10.3390/vaccines7030117
Abstract: Universal influenza virus vaccine candidates that focus on the conserved hemagglutinin (HA) stalk domain and the extracellular domain of the matrix protein 2 (M2e) have been developed to increase the breadth of protection against multiple… read more here.
Keywords: virus vaccine; influenza virus; hemagglutinin; m2e ... See more keywords
Generation and Characterization of Universal Live-Attenuated Influenza Vaccine Candidates Containing Multiple M2e Epitopes
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DOI: 10.3390/vaccines8040648
Abstract: Influenza viruses constantly evolve, reducing the overall protective effect of routine vaccination campaigns. Many different strategies are being explored to design universal influenza vaccines capable of protecting against evolutionary diverged viruses. The ectodomain of influenza… read more here.
Keywords: laiv; 4m2e viruses; m2e; m2e specific ... See more keywords
Transdermal Vaccination with the Matrix-2 Protein Virus-like Particle (M2e VLP) Induces Immunity in Mice against Influenza A Virus
Sign Up to like & getrecommendations! Published in 2021 at "Vaccines"
DOI: 10.3390/vaccines9111324
Abstract: In this study, our goal was to utilize the extracellular domain matrix-2 protein virus-like particle (M2e VLP) that has been found to be highly conserved amongst all strains of influenza and could serve as a… read more here.
Keywords: matrix protein; m2e; virus; m2e vlp ... See more keywords