The M476W/Q482H mutation of procaspase-8 restored caspase-8-mediated apoptosis.
Sign Up to like & getrecommendations! Published in 2019 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2019.05.023
Abstract: Caspase-8 is an initiator of apoptotic signalling, and aberrations in procaspase-8 have been verified to be associated with malignant tumours. In previous studies, various procaspase-8 mutants were identified in AML patients, such as Q482H and… read more here.
Keywords: q482h mutation; caspase; apoptosis; m476w q482h ... See more keywords