RNA 5‐Methylcytosine Modification Regulates Vegetative Development Associated with H3K27 Trimethylation in Arabidopsis
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Science"
DOI: 10.1002/advs.202204885
Abstract: Methylating RNA post‐transcriptionally is emerging as a significant mechanism of gene regulation in eukaryotes. The crosstalk between RNA methylation and histone modification is critical for chromatin state and gene expression in mammals. However, it is… read more here.
Keywords: modification; trimethylation; rna; m5c ... See more keywords
Development of the expression and prognostic significance of m5C‐related LncRNAs in breast cancer
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DOI: 10.1002/cam4.5500
Abstract: 5‐Methylcytosine (m5C) methylation is a major epigenetic RNA modification and is closely related to tumorigenesis in various cancers. This study aimed to explore the prognostic value of m5C‐related lncRNAs in breast cancer. read more here.
Keywords: m5c related; related lncrnas; breast cancer; m5c ... See more keywords
mRNA m5C Alteration in Azacitidine Demethylation Treatment of Acute Myeloid Leukemia
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DOI: 10.1002/mc.23864
Abstract: The DNA demethylating therapy with azacitidine (AZA) is a promising therapeutic strategy for elderly patients with acute myeloid leukemia (AML). AZA primarily inhibits DNA methylation, promotes cell differentiation and apoptosis in AML. However, as a… read more here.
Keywords: aza; acute myeloid; m5c; mrna m5c ... See more keywords
Dynamic transcriptomic m5C and its regulatory role in RNA processing
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DOI: 10.1002/wrna.1639
Abstract: RNA 5‐methylcytosine (m5C) is a prevalent RNA modification in multiple RNA species, including messenger RNAs (mRNAs), transfer RNAs (tRNAs), ribosomal RNAs (rRNAs), and noncoding RNAs (ncRNAs), and broadly distributed from archaea, prokaryotes to eukaryotes. The… read more here.
Keywords: seq; transcriptomic m5c; dynamic transcriptomic; rna ... See more keywords
m5C modification of mRNA serves a DNA damage code to promote homologous recombination
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DOI: 10.1038/s41467-020-16722-7
Abstract: Recruitment of DNA repair proteins to DNA damage sites is a critical step for DNA repair. Post-translational modifications of proteins at DNA damage sites serve as DNA damage codes to recruit specific DNA repair factors.… read more here.
Keywords: dna damage; m5c; dna repair; damage ... See more keywords
Prediction of m6A and m5C at single-molecule resolution reveals a transcriptome-wide co-occurrence of RNA modifications
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DOI: 10.1038/s41467-024-47953-7
Abstract: The epitranscriptome embodies many new and largely unexplored functions of RNA. A significant roadblock hindering progress in epitranscriptomics is the identification of more than one modification in individual transcript molecules. We address this with CHEUI… read more here.
Keywords: wide occurrence; m5c; m6a m5c; transcriptome wide ... See more keywords
A cohort of mRNAs undergo high-stoichiometry NSUN6-mediated site-specific m5C modification
Sign Up to like & getrecommendations! Published in 2025 at "Nature Communications"
DOI: 10.1038/s41467-025-60873-4
Abstract: mRNA modifications are vital in regulating cellular processes. Beyond N6-methyladenosine (m6A), most other internal mRNA modifications lack dedicated catalytic machinery and are typically introduced by tRNA-modifying enzymes. The distribution and stoichiometry of these modifications on… read more here.
Keywords: m5c modification; m5c; cell migration; site ... See more keywords
m5C mRNAs on the move
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DOI: 10.1038/s41580-019-0167-6
Abstract: Cytosine methylation (m5C) in mRNAs is important for their transport to distant tissues in plants. read more here.
Keywords: m5c mrnas; m5c; biology; mrnas move ... See more keywords
m5C related-regulator-mediated methylation modification patterns and prognostic significance in breast cancer
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DOI: 10.1038/s41598-024-77389-4
Abstract: 5-Methylcytosine (m5C) is closely associated with cancer. However, the role of m5C in breast cancer(BC)remains unclear. This study combined single-cell RNA sequencing (scRNA-Seq) and transcriptomics datasets to screen m5C regulators associated with BC progression and… read more here.
Keywords: breast cancer; modification patterns; m5c; m5c regulators ... See more keywords
5-methylcytosine (m5C) RNA modification controls the innate immune response to virus infection by regulating type I interferons
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2123338119
Abstract: Significance 5-methylcytosine (m5C) is a common RNA methylation. However, its biological functions remain a mystery. Here, we discover that depletion of NSUN2, an m5C methyltransferase, leads to an enhanced type I interferon (IFN) response, which… read more here.
Keywords: rna modification; m5c rna; rna; methylcytosine m5c ... See more keywords
m5c-iEnsem: 5-methylcytosine sites identification through ensemble models
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DOI: 10.1093/bioinformatics/btae722
Abstract: Abstract Motivation 5-Methylcytosine (m5c), a modified cytosine base, arises from adding a methyl group at the 5th carbon position. This modification is a prevalent form of post-transcriptional modification (PTM) found in various types of RNA.… read more here.
Keywords: m5c; m5c iensem; ensemble models; iensem methylcytosine ... See more keywords