RNA 5‐Methylcytosine Modification Regulates Vegetative Development Associated with H3K27 Trimethylation in Arabidopsis
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Science"
DOI: 10.1002/advs.202204885
Abstract: Methylating RNA post‐transcriptionally is emerging as a significant mechanism of gene regulation in eukaryotes. The crosstalk between RNA methylation and histone modification is critical for chromatin state and gene expression in mammals. However, it is… read more here.
Keywords: modification; trimethylation; rna; m5c ... See more keywords
Development of the expression and prognostic significance of m5C‐related LncRNAs in breast cancer
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DOI: 10.1002/cam4.5500
Abstract: 5‐Methylcytosine (m5C) methylation is a major epigenetic RNA modification and is closely related to tumorigenesis in various cancers. This study aimed to explore the prognostic value of m5C‐related lncRNAs in breast cancer. read more here.
Keywords: m5c related; related lncrnas; breast cancer; m5c ... See more keywords
Dynamic transcriptomic m5C and its regulatory role in RNA processing
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DOI: 10.1002/wrna.1639
Abstract: RNA 5‐methylcytosine (m5C) is a prevalent RNA modification in multiple RNA species, including messenger RNAs (mRNAs), transfer RNAs (tRNAs), ribosomal RNAs (rRNAs), and noncoding RNAs (ncRNAs), and broadly distributed from archaea, prokaryotes to eukaryotes. The… read more here.
Keywords: seq; transcriptomic m5c; dynamic transcriptomic; rna ... See more keywords
m5C modification of mRNA serves a DNA damage code to promote homologous recombination
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DOI: 10.1038/s41467-020-16722-7
Abstract: Recruitment of DNA repair proteins to DNA damage sites is a critical step for DNA repair. Post-translational modifications of proteins at DNA damage sites serve as DNA damage codes to recruit specific DNA repair factors.… read more here.
Keywords: dna damage; m5c; dna repair; damage ... See more keywords
m5C mRNAs on the move
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DOI: 10.1038/s41580-019-0167-6
Abstract: Cytosine methylation (m5C) in mRNAs is important for their transport to distant tissues in plants. read more here.
Keywords: m5c mrnas; m5c; biology; mrnas move ... See more keywords
5-methylcytosine (m5C) RNA modification controls the innate immune response to virus infection by regulating type I interferons
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2123338119
Abstract: Significance 5-methylcytosine (m5C) is a common RNA methylation. However, its biological functions remain a mystery. Here, we discover that depletion of NSUN2, an m5C methyltransferase, leads to an enhanced type I interferon (IFN) response, which… read more here.
Keywords: rna modification; m5c rna; rna; methylcytosine m5c ... See more keywords
Long-Term m5C Methylome Dynamics Parallel Phenotypic Adaptation in the Cyanobacterium Trichodesmium
Sign Up to like & getrecommendations! Published in 2020 at "Molecular Biology and Evolution"
DOI: 10.1093/molbev/msaa256
Abstract: Abstract A major challenge in modern biology is understanding how the effects of short-term biological responses influence long-term evolutionary adaptation, defined as a genetically determined increase in fitness to novel environments. This is particularly important… read more here.
Keywords: term; long term; co2; m5c ... See more keywords
A general strategy exploiting m5C duplex-remodelling effect for selective detection of RNA and DNA m5C methyltransferase activity in cells
Sign Up to like & getrecommendations! Published in 2019 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkz1047
Abstract: Abstract RNA:5-methylcytosine (m5C) methyltransferases are currently the focus of intense research following a series of high-profile reports documenting their physiological links to several diseases. However, no methods exist which permit the specific analysis of RNA:m5C… read more here.
Keywords: methyltransferase; rna; dna m5c; m5c ... See more keywords
Excision of the doubly methylated base N4,5-dimethylcytosine from DNA by Escherichia coli Nei and Fpg proteins
Sign Up to like & getrecommendations! Published in 2018 at "Philosophical Transactions of the Royal Society B: Biological Sciences"
DOI: 10.1098/rstb.2017.0337
Abstract: Cytosine (C) in DNA is often modified to 5-methylcytosine (m5C) to execute important cellular functions. Despite the significance of m5C for epigenetic regulation in mammals, damage to m5C has received little attention. For instance, almost… read more here.
Keywords: dna; escherichia coli; fpg; m5c ... See more keywords
Transcriptome-Wide Mapping of RNA 5-Methylcytosine in Arabidopsis mRNAs and Noncoding RNAs
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DOI: 10.1105/tpc.16.00751
Abstract: Transcriptome-wide quantitative mapping of 5-methylcytosine in Arabidopsis via RNA bisulfite sequencing reveals crucial links between this modification and cell division and plant stress pathways. Posttranscriptional methylation of RNA cytosine residues to 5-methylcytosine (m5C) is an… read more here.
Keywords: methylcytosine arabidopsis; mapping; m5c; transcriptome wide ... See more keywords
m5C and m6A modification of long noncoding NKILA accelerates cholangiocarcinoma progression via the miR‐582‐3p‐YAP1 axis
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DOI: 10.1111/liv.15240
Abstract: Cholangiocarcinoma (CCA) is a severe malignancy originating from the bile duct and the second most common primary liver cancer. NF‐kappa B interacting lncRNA (NKILA) is a functional lncRNA, which play important role in human cancers.… read more here.
Keywords: m6a modification; mir 582; cca; via mir ... See more keywords