YBX1 promotes type H vessel–dependent bone formation in an m5C-dependent manner
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DOI: 10.1172/jci.insight.172345
Abstract: RNA-binding proteins (RBPs) interact with RNA and ubiquitously regulate RNA transcripts during their life cycle, playing a fundamental role in the progression of angiogenesis-related diseases. In the skeletal system, endothelium-dependent angiogenesis is indispensable for bone… read more here.
Keywords: dependent bone; m5c dependent; bone formation; bone ... See more keywords
NSUN2 promotes leukemogenesis by ferritin heavy chain 1-mediated anti-ferroptosis and enhancing global protein synthesis in an m5C-dependent manner in B-acute lymphoblastic leukemia
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DOI: 10.1186/s13148-025-01994-x
Abstract: NOP2/Sun RNA methyltransferase family member 2 (NSUN2) catalyzes 5-methylcytosine (m5C) modifications in tRNA, rRNA, and mRNA, playing critical roles in various malignancies. However, its expression and functional relevance in B-acute lymphoblastic leukemia (B-ALL) remain largely… read more here.
Keywords: m5c dependent; m5c; protein synthesis; global protein ... See more keywords