A cohort of mRNAs undergo high-stoichiometry NSUN6-mediated site-specific m5C modification
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DOI: 10.1038/s41467-025-60873-4
Abstract: mRNA modifications are vital in regulating cellular processes. Beyond N6-methyladenosine (m6A), most other internal mRNA modifications lack dedicated catalytic machinery and are typically introduced by tRNA-modifying enzymes. The distribution and stoichiometry of these modifications on… read more here.
Keywords: m5c modification; m5c; cell migration; site ... See more keywords
m5C RNA modification in colorectal cancer: mechanisms and therapeutic targets
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DOI: 10.1186/s12967-025-06985-3
Abstract: 5-Methylcytosine (m5C), an important RNA modification, has been extensively studied in colorectal cancer (CRC). In recent years, with advances in high-throughput sequencing technology and RNA modification detection tools, the role of m5C modification in tumorigenesis… read more here.
Keywords: m5c modification; cancer; rna modification; medicine ... See more keywords
Identification of the Expression Patterns and Potential Prognostic Role of 5-Methylcytosine Regulators in Hepatocellular Carcinoma
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DOI: 10.3389/fcell.2022.842220
Abstract: Background: Hepatocellular carcinoma (HCC) is the most common primary liver cancer with a poor prognosis. 5-methylcytosine (m5C) modification plays a nonnegligible role in tumor pathogenesis and progression. However, little is known about the role of… read more here.
Keywords: m5c modification; prognosis; hcc; hepatocellular carcinoma ... See more keywords
Roles of m5C RNA Modification Patterns in Biochemical Recurrence and Tumor Microenvironment Characterization of Prostate Adenocarcinoma
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.869759
Abstract: Background Prostate cancer is the second most common cancer with a high risk of biochemical recurrence (BCR) among men. Recently, 5-methylcytosine (m5C) modification has attracted more attention as a new layer of RNA post-transcriptional regulation.… read more here.
Keywords: modification; tumor; prostate; roles m5c ... See more keywords
Modification of m5C regulators in sarcoma can guide different immune infiltrations as well as immunotherapy
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DOI: 10.3389/fsurg.2022.948371
Abstract: Background Recent studies have found that 5-methylcytosine (m5C) modulators are associated with the prognosis and treatment of cancer. However, the relevance of m5C modulators in sarcoma prognosis and the tumour microenvironment is unclear. Methods We… read more here.
Keywords: m5c score; modification; m5c regulators; m5c ... See more keywords
5-Methylcytosine (m5C) Modification Patterns and Tumor Immune Infiltration Characteristics in Clear Cell Renal Cell Carcinoma
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DOI: 10.3390/curroncol30010044
Abstract: Recently, studies have revealed the prognostic value of 5-methylcytosine (m5C) in clear cell renal cell carcinoma (ccRCC). However, the role of m5C methylation in ccRCC immune infiltration and the immunotherapeutic response remains unknown. Based on… read more here.
Keywords: immune infiltration; m5c modification; modification patterns;
A Cross-Tissue Investigation of Molecular Targets and Physiological Functions of Nsun6 Using Knockout Mice
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DOI: 10.3390/ijms23126584
Abstract: The 5-methylcytosine (m5C) modification on an mRNA molecule is deposited by Nsun2 and its paralog Nsun6. While the physiological functions of Nsun2 have been carefully studied using gene knockout (KO) mice, the physiological functions of… read more here.
Keywords: physiological functions; knockout mice; mice; functions nsun6 ... See more keywords
Epitranscriptomic mechanisms and implications of RNA m5C modification in cancer
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DOI: 10.7150/thno.112332
Abstract: Cancer is an extremely complex disease characterized by abnormal cell growth due to genetic and environmental factors. With the rise of the field of epigenetic transcriptomics, 5-methylcytidine (m5C) modification has been identified as one of… read more here.
Keywords: m5c modification; cancer; epitranscriptomic mechanisms; mechanisms implications ... See more keywords
Lactylation-driven NSUN2-mediated RNA m5C modification promotes perineural invasion in pancreatic cancer.
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DOI: 10.7150/thno.122294
Abstract: Background: Perineural invasion (PNI) is a key biological feature underpinning the high malignancy and poor prognosis of pancreatic ductal adenocarcinoma (PDAC). Lysine lactylation (Kla), a metabolite-stress-induced post-translational modification, plays crucial regulatory roles in diverse biological… read more here.
Keywords: m5c modification; lactylation; perineural invasion; invasion ... See more keywords