M694I variant of MEFV drives pathogenesis of familial Mediterranean fever through enhanced Th17 cell differentiation.
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DOI: 10.1093/rheumatology/keaf336
Abstract: OBJECTIVE To investigate how the M694I variant of MEFV contributes to familial Mediterranean fever (FMF) pathophysiology using knock-in mice, focusing on T helper 17 (Th17) cell responses and the underlying molecular mechanisms. METHODS Human MEFV… read more here.
Keywords: differentiation; m694i; th17; cell ... See more keywords