FTO, m6Am, and the hypothesis of reversible epitranscriptomic mRNA modifications
Sign Up to like & getrecommendations! Published in 2018 at "FEBS Letters"
DOI: 10.1002/1873-3468.13092
Abstract: The fate of mRNA is regulated by epitranscriptomic nucleotide modifications, the most abundant of which is N6‐methyladenosine (m6A). Although the pattern and distribution of m6A in mRNA is mediated by specific methyltransferases, a recent hypothesis… read more here.
Keywords: m6am hypothesis; fto m6am; hypothesis reversible; m6a ... See more keywords
Downregulation of m6A writer complex member METTL14 in bladder urothelial carcinoma suppresses tumor aggressiveness
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Oncology"
DOI: 10.1002/1878-0261.13181
Abstract: N6‐methyladenosine (m6A) and its regulatory proteins have been associated with tumorigenesis in several cancer types. However, knowledge on the mechanistic network related to m6A in bladder cancer (BlCa) is rather limited, requiring further investigation of… read more here.
Keywords: writer complex; m6a; tumor aggressiveness; m6a writer ... See more keywords
m6A Reader YTHDF1‐Targeting Engineered Small Extracellular Vesicles for Gastric Cancer Therapy via Epigenetic and Immune Regulation
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Materials"
DOI: 10.1002/adma.202204910
Abstract: N6‐methyladenosine (m6A) modulators decide the fate of m6A‐modified transcripts and drive cancer development. RNA interference targeting m6A modulators promise to be an emerging cancer therapy but is challenging due to its poor tumor targeting and… read more here.
Keywords: cancer therapy; ythdf1; gastric cancer; m6a ... See more keywords
Characterization of m6A regulator‐mediated methylation modification patterns and tumor microenvironment infiltration in acute myeloid leukemia
Sign Up to like & getrecommendations! Published in 2022 at "Cancer Medicine"
DOI: 10.1002/cam4.4531
Abstract: Previous studies have confirmed the existence of epigenetic regulation of immune responses in acute myeloid leukemia. However, the potential role of RNA N6‐methyladenosine (m6A) remodeling in tumor microenvironment (TME) infiltration remains unclear. read more here.
Keywords: infiltration; myeloid leukemia; tumor microenvironment; acute myeloid ... See more keywords
Fat mass and obesity‐associated protein regulates lipogenesis via m6A modification in fatty acid synthase mRNA
Sign Up to like & getrecommendations! Published in 2020 at "Cell Biology International"
DOI: 10.1002/cbin.11490
Abstract: As the first identified N6‐methyladenosine (m6A) demethylase, fat mass and obesity‐associated (FTO) protein is associated with fatty acid synthase (FASN) and lipid accumulation. However, little is known about the regulatory role of FTO in the… read more here.
Keywords: protein; m6a modification; m6a; obesity ... See more keywords
Fat mass and obesity‐associated protein alleviates Aβ1–40 induced retinal pigment epithelial cells degeneration via PKA/CREB signaling pathway
Sign Up to like & getrecommendations! Published in 2022 at "Cell Biology International"
DOI: 10.1002/cbin.11959
Abstract: Amyloid‐β (Aβ) is thought to be a critical pathologic factor of retinal pigment epithelium (RPE) degeneration in age‐related macular degeneration (AMD). Aβ induces inflammatory responses in RPE cells and recent studies demonstrate the N6‐methyladenosine (m6A)… read more here.
Keywords: degeneration; pka; rpe degeneration; retinal pigment ... See more keywords
The “m6A writer” METTL3 and the “m6A reader” IGF2BP2 regulate cutaneous T‐cell lymphomas progression via CDKN2A
Sign Up to like & getrecommendations! Published in 2022 at "Hematological Oncology"
DOI: 10.1002/hon.3005
Abstract: It has been established that Cutaneous T‐Cell lymphomas (CTCL) are caused by the monoclonal proliferation of T lymphocytes in the skin. This heterogeneous group of diseases represents a significant source of distress to patients since… read more here.
Keywords: progression; ctcl; cell lymphomas; m6a ... See more keywords
Bisphenol A exposure induces testicular oxidative damage via FTO/m6A/Nrf2 axis during postnatal development in mice
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Applied Toxicology"
DOI: 10.1002/jat.4417
Abstract: Bisphenol A (BPA), a commonly used plasticizer in the production of polycarbonate plastics and epoxy resins, has been shown to induce male reproductive toxicity. However, the effects of BPA exposure on early testicular development have… read more here.
Keywords: development; postnatal development; testicular oxidative; m6a ... See more keywords
Identification of an m6A‐related lncRNA prognostic signature in colorectal cancer
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Biochemical and Molecular Toxicology"
DOI: 10.1002/jbt.23239
Abstract: Data sets of colorectal cancer (CRC) were obtained from The Cancer Genome Atlas (TCGA), three N6‐methyladenosine (m6A) subtypes were identified using 21 m6A‐related long noncoding RNAs (lncRNAs) and differential m6A subtypes of different CRC tumors… read more here.
Keywords: related lncrna; m6a related; risk; colorectal cancer ... See more keywords
Regulatory Role of N6‐methyladenosine (m6A) Methylation in RNA Processing and Human Diseases
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DOI: 10.1002/jcb.25967
Abstract: N6‐methyladenosine (m6A) modification is an abundant and conservative RNA modification in bacterial and eukaryotic cells. m6A modification mainly occurs in the 3′ untranslated regions (UTRs) and near the stop codons of mRNA. Diverse strategies have… read more here.
Keywords: methyladenosine m6a; m6a modification; rna processing; m6a ... See more keywords
RNA demethylase ALKBH5 regulates hypopharyngeal squamous cell carcinoma ferroptosis by posttranscriptionally activating NFE2L2/NRF2 in an m6A‐IGF2BP2‐dependent manner
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Clinical Laboratory Analysis"
DOI: 10.1002/jcla.24514
Abstract: Having emerged as the most abundant posttranscriptional internal mRNA modification in eukaryotes, N6‐methyladenosine (m6A) has attracted tremendous scientific interest in recent years. However, the functional importance of the m6A methylation machinery in ferroptosis regulation in… read more here.
Keywords: cell carcinoma; hypopharyngeal squamous; squamous cell; m6a ... See more keywords