The Potential Role of N6-Methyladenosine (m6A) Demethylase Fat Mass and Obesity-Associated Gene (FTO) in Human Cancers
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DOI: 10.2147/ott.s283417
Abstract: Abstract N6-methyladenosine (m6A) demethylase fat mass and obesity-associated gene(FTO), previously recognized to be related with obesity and diabetes, was gradually discovered to be dysregulated in multiple cancers and plays an oncogenic or tumor-suppressive role. However,… read more here.
Keywords: role; fat mass; obesity; methyladenosine m6a ... See more keywords
Impact of m6A demethylase (ALKBH5, FTO) genetic polymorphism and expression levels on the development of pulmonary tuberculosis
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DOI: 10.3389/fcimb.2022.1074380
Abstract: Objective The m6A methylation was involved in the pathogenesis of pulmonary tuberculosis (PTB), and our study aimed to reveal the potential association of m6A demethylase (ALKBH5, FTO) genes variation, expression levels and PTB. Methods Eight… read more here.
Keywords: alkbh5 fto; m6a demethylase; ptb patients; expression levels ... See more keywords
FTO m6A Demethylase in Obesity and Cancer: Implications and Underlying Molecular Mechanisms
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DOI: 10.3390/ijms23073800
Abstract: Fat mass and obesity-associated protein (FTO) is the first reported RNA N6-methyladenosine (m6A) demethylase in eukaryotic cells. m6A is considered as the most abundant mRNA internal modification, which modulates several cellular processes including alternative splicing,… read more here.
Keywords: obesity; fto m6a; m6a demethylase; cancer ... See more keywords
m6A Demethylase ALKBH5 Restrains PEDV Infection by Regulating GAS6 Expression in Porcine Alveolar Macrophages
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DOI: 10.3390/ijms23116191
Abstract: Porcine epidemic diarrhea virus (PEDV) is a burdensome coronavirus for the global pig industry. Although its fecal-oral route has been well-recognized, increasing evidence suggests that PEDV can also spread through airborne routes, indicating that the… read more here.
Keywords: infection; alkbh5; pedv infection; demethylase alkbh5 ... See more keywords