m6A-dependent upregulation of TRAF6 by METTL3 is associated with metastatic osteosarcoma
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Bone Oncology"
DOI: 10.1016/j.jbo.2022.100411
Abstract: Highlights • METTL3 is highly expressed in osteosarcoma.• METTL3 downregulation inhibits metastases of osteosarcoma cells.• m6A regulates osteosarcoma cell activity.• METTL3 modifies TRAF6 activity via m6A.• TRAF6 inhibits the repressive effects of sh-METTL3 on osteosarcoma… read more here.
Keywords: upregulation traf6; mettl3; m6a dependent; osteosarcoma ... See more keywords
A Unique m6A-Dependent Restriction Endonuclease from an Archaeal Virus
Sign Up to like & getrecommendations! Published in 2023 at "Microbiology Spectrum"
DOI: 10.1128/spectrum.04262-22
Abstract: Many modification-dependent restriction endonucleases (MDREs) were identified in prokaryotes and recognized modified cytosine bases, such as 5-methylcytosine (5mC), 5-hydroxymethylcytosine (5hmC), and glucosyl-5-hydroxymethylcytosine (g5hmC). The first virus-derived MDRE (HHPV4I) from the archaeal virus HHPV4 was identified… read more here.
Keywords: hhpv4i; restriction; m6a dependent; dependent restriction ... See more keywords