RNA m6A methylation in cancer
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Oncology"
DOI: 10.1002/1878-0261.13326
Abstract: N6‐methyladenosine (m6A) is one of the most abundant internal modifications in eukaryotic messenger RNAs (mRNAs) and non‐coding RNAs (ncRNAs). It is a reversible and dynamic RNA modification that has been observed in both internal coding… read more here.
Keywords: m6a methylation; cancer; rna m6a;
Dynamic control of chromatin-associated m6A methylation regulates nascent RNA synthesis.
Sign Up to like & getrecommendations! Published in 2022 at "Molecular cell"
DOI: 10.1016/j.molcel.2022.02.006
Abstract: N6-methyladenosine (m6A) methylation is co-transcriptionally deposited on mRNA, but a possible role of m6A on transcription remains poorly understood. Here, we demonstrate that the METTL3/METTL14/WTAP m6A methyltransferase complex (MTC) is localized to many promoters and… read more here.
Keywords: m6a modification; promoters enhancers; integrator; m6a ... See more keywords
RNA m6A methylation orchestrates cancer growth and metastasis via macrophage reprogramming
Sign Up to like & getrecommendations! Published in 2021 at "Nature Communications"
DOI: 10.1038/s41467-021-21514-8
Abstract: N6-methyladenosine (m6A) is a reversible mRNA modification that has been shown to play important roles in various biological processes. However, the roles of m6A modification in macrophages are still unknown. Here, we discover that ablation… read more here.
Keywords: growth metastasis; macrophage; growth; rna m6a ... See more keywords
METTL3-mediated m6A methylation negatively modulates autophagy to support porcine blastocyst development‡
Sign Up to like & getrecommendations! Published in 2021 at "Biology of Reproduction"
DOI: 10.1093/biolre/ioab022
Abstract: Abstract N6-methyladenosine (m6A) catalyzed by METTL3 regulates the maternal-to-zygotic transition in zebrafish and mice. However, the role and mechanism of METTL3-mediated m6A methylation in blastocyst development remains unclear. Here, we show that METTL3-mediated m6A methylation… read more here.
Keywords: mettl3 mediated; mediated m6a; blastocyst development; blastocyst ... See more keywords
Dynamic landscape and evolution of m6A methylation in human
Sign Up to like & getrecommendations! Published in 2020 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkaa347
Abstract: Abstract m6A is a prevalent internal modification in mRNAs and has been linked to the diverse effects on mRNA fate. To explore the landscape and evolution of human m6A, we generated 27 m6A methylomes across… read more here.
Keywords: landscape evolution; m6a methylation; m6a;
The Cancer Genome Atlas (TCGA) based m6A methylation-related genes predict prognosis in rectosigmoid cancer
Sign Up to like & getrecommendations! Published in 2022 at "Medicine"
DOI: 10.1097/md.0000000000032328
Abstract: N6-methyladenosine (m6A) methylation plays an important role in the occurrence and development of tumors. This study aimed to explore the effects of m6A methylation regulatory genes on rectosigmoid cancer (RSC). RNA-seq data and related clinical… read more here.
Keywords: methylation; methylation regulatory; regulatory genes; m6a methylation ... See more keywords
Prognostic and therapeutic implication of m6A methylation in Crohn disease
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DOI: 10.1097/md.0000000000032399
Abstract: Background: N6-methyladenosine (m6A) methylation has been reported to participate in inflammatory bowel disease (including Crohn disease [CD]). However, the prognostic and therapeutic implication of m6A methylation modification in CD is still unclear. Methods: Genomic information… read more here.
Keywords: m6a methylation; disease; expression; m6a regulators ... See more keywords
N6‐methyladenosine functions and its role in skin cancer
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DOI: 10.1111/exd.14696
Abstract: N6‐methyladenosine (m6A) methylation is the most abundant mammalian mRNA modification. m6A regulates RNA processing, splicing, nucleation, translation and stability by transferring, removing and recognizing m6A methylation sites, which are critical for cancer initiation, progression, metabolism… read more here.
Keywords: skin cancers; skin; m6a methylation; skin cancer ... See more keywords
Methionine deficiency facilitates antitumour immunity by altering m6A methylation of immune checkpoint transcripts
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DOI: 10.1136/gutjnl-2022-326928
Abstract: Objective Methionine metabolism is involved in a myriad of cellular functions, including methylation reactions and redox maintenance. Nevertheless, it remains unclear whether methionine metabolism, RNA methylation and antitumour immunity are molecularly intertwined. Design The antitumour… read more here.
Keywords: m6a methylation; antitumour immunity; immunity; methionine metabolism ... See more keywords
LncRNA UCA1 Promotes the Progression of AML by Upregulating the Expression of CXCR4 and CYP1B1 by Affecting the Stability of METTL14
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Oncology"
DOI: 10.1155/2022/2756986
Abstract: Objective Increasing numbers of studies have proved that m6A methylation plays crucial roles in different cancers. However, how lncRNA regulates m6A methylation and participates in acute myeloid leukemia (AML) remains unclear. Therefore, this study aims… read more here.
Keywords: expression; methylation; aml; cyp1b1 ... See more keywords
Comprehensive Analysis and Functional Characteristics of Differential Expression of N6-Methyladenosine Methylation Modification in the Whole Transcriptome of Rheumatoid Arthritis
Sign Up to like & getrecommendations! Published in 2022 at "Mediators of Inflammation"
DOI: 10.1155/2022/4766992
Abstract: N6-methyladenosine (m6A) modification is the most prevalent chemical modification in eukaryotic mRNA and is associated with the development of various immune diseases. However, the role of m6A methylation in rheumatoid arthritis (RA) development is unclear.… read more here.
Keywords: modification; m6a methylation; rheumatoid arthritis; expression ... See more keywords