Epitranscriptomic RNA m6A Modification in Cancer Therapy Resistance: Challenges and Unrealized Opportunities
Sign Up to like & getrecommendations! Published in 2024 at "Advanced Science"
DOI: 10.1002/advs.202403936
Abstract: Significant advances in the development of new cancer therapies have given rise to multiple novel therapeutic options in chemotherapy, radiotherapy, immunotherapy, and targeted therapies. Although the development of resistance is often reported along with temporary… read more here.
Keywords: cancer; resistance; m6a modification; cancer therapy ... See more keywords
N6‐ Methyladenosine defines a new checkpoint in γδ T cell development
Sign Up to like & getrecommendations! Published in 2023 at "BioEssays"
DOI: 10.1002/bies.202300002
Abstract: T cells, which are derived from hematopoietic stem cells (HSCs), are the most important components of adaptive immune system. Based on the expression of αβ and γδ receptors, T cells are mainly divided into αβ… read more here.
Keywords: cell development; development; m6a modification; checkpoint cell ... See more keywords
Fat mass and obesity‐associated protein regulates lipogenesis via m6A modification in fatty acid synthase mRNA
Sign Up to like & getrecommendations! Published in 2020 at "Cell Biology International"
DOI: 10.1002/cbin.11490
Abstract: As the first identified N6‐methyladenosine (m6A) demethylase, fat mass and obesity‐associated (FTO) protein is associated with fatty acid synthase (FASN) and lipid accumulation. However, little is known about the regulatory role of FTO in the… read more here.
Keywords: protein; m6a modification; m6a; obesity ... See more keywords
The m6A modification of ACSL4 mRNA sensitized esophageal squamous cell carcinoma to irradiation via accelerating ferroptosis
Sign Up to like & getrecommendations! Published in 2024 at "Cell Biology International"
DOI: 10.1002/cbin.12245
Abstract: Radioresistance is a major obstacle for the therapy of esophageal squamous cell carcinoma (ESCC) and lead to a poor prognosis. Ferroptosis is supposed to be responsible for radioresistance. However, the ferroptosis‐induced radioresistance in ESCC and… read more here.
Keywords: ferroptosis; irradiation via; m6a modification; cell ... See more keywords
RNA methylase RBM15 facilitates malignant progression of colorectal cancer through regulating E2F2 in an m6A modification‐dependent manner
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Biochemical and Molecular Toxicology"
DOI: 10.1002/jbt.70014
Abstract: Recently, RBM15 has emerged as an oncogenic factor in a majority of tumors. However, the mechanism is unclear that accounts for how RBM15‐induces colorectal cancer (CRC) progression and it is in need of further study.… read more here.
Keywords: colorectal cancer; m6a; e2f2 m6a; m6a modification ... See more keywords
Regulatory Role of N6‐methyladenosine (m6A) Methylation in RNA Processing and Human Diseases
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.25967
Abstract: N6‐methyladenosine (m6A) modification is an abundant and conservative RNA modification in bacterial and eukaryotic cells. m6A modification mainly occurs in the 3′ untranslated regions (UTRs) and near the stop codons of mRNA. Diverse strategies have… read more here.
Keywords: methyladenosine m6a; m6a modification; rna processing; m6a ... See more keywords
ALKBH5 gene polymorphisms and Wilms tumor risk in Chinese children: A five‐center case‐control study
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Clinical Laboratory Analysis"
DOI: 10.1002/jcla.23251
Abstract: Wilms tumor is a frequently diagnosed renal cancer among children with unclear genetic causes. N6‐methyladenosine (m6A) modification genes play critical roles in tumorigenesis. However, whether genetic variations of m6A modification genes predispose to Wilms tumor… read more here.
Keywords: m6a modification; gene polymorphisms; alkbh5 gene; wilms tumor ... See more keywords
N6‐methyladenosine modification participates in neoplastic immunoregulation and tumorigenesis
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.30730
Abstract: This review aims to provide insight into the role of N6‐methyladenosine (m6A) modification in neoplastic immunity and subsequent tumorigenesis. m6A modification, which is catalyzed by methyltransferases, demethylases and reader proteins, has emerged as a widespread… read more here.
Keywords: modification participates; modification; m6a modification; tumorigenesis ... See more keywords
The emerging roles of the interaction between m6A modification and c‐Myc in driving tumorigenesis and development
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.30733
Abstract: N6‐methyladenosine (m6A) is an extremely common and conservative posttranscriptional modification, that can specifically target and regulate the expression or stability of a series of tumor‐related genes, thus playing critical roles in the occurrence and development… read more here.
Keywords: modification; m6a modification; development; modification myc ... See more keywords
Abnormal stress promotes intervertebral disc degeneration through WTAP/YTHDF2‐dependent TIMP3 m6A modification
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.31219
Abstract: Mechanical environment worsening is an important predisposing factor that accelerates intervertebral disc degeneration (IDD), but its specific regulatory mechanisms remain unclear. In this study, we reveal the molecular mechanisms of WTAP/YTHDF2‐mediated m6A modification in abnormal… read more here.
Keywords: abnormal stress; intervertebral disc; timp3; m6a modification ... See more keywords
ALKBH5‐Mediated m6A Modification of XBP1 Facilitates NSCLC Progression Through the IL‐6–JAK–STAT3 Pathway
Sign Up to like & getrecommendations! Published in 2024 at "Molecular Carcinogenesis"
DOI: 10.1002/mc.23826
Abstract: The X‐box‐binding protein 1 (XBP1) is an important transcription factor during endoplasmic reticulum stress response, which was reported as an oncogene in non‐small cell lung cancer (NSCLC) tumorigenesis and development. However, the regulatory mechanism of… read more here.
Keywords: modification xbp1; m6a modification; nsclc progression; xbp1 ... See more keywords