N6‐ Methyladenosine defines a new checkpoint in γδ T cell development
Sign Up to like & getrecommendations! Published in 2023 at "BioEssays"
DOI: 10.1002/bies.202300002
Abstract: T cells, which are derived from hematopoietic stem cells (HSCs), are the most important components of adaptive immune system. Based on the expression of αβ and γδ receptors, T cells are mainly divided into αβ… read more here.
Keywords: cell development; development; m6a modification; checkpoint cell ... See more keywords
Fat mass and obesity‐associated protein regulates lipogenesis via m6A modification in fatty acid synthase mRNA
Sign Up to like & getrecommendations! Published in 2020 at "Cell Biology International"
DOI: 10.1002/cbin.11490
Abstract: As the first identified N6‐methyladenosine (m6A) demethylase, fat mass and obesity‐associated (FTO) protein is associated with fatty acid synthase (FASN) and lipid accumulation. However, little is known about the regulatory role of FTO in the… read more here.
Keywords: protein; m6a modification; m6a; obesity ... See more keywords
Regulatory Role of N6‐methyladenosine (m6A) Methylation in RNA Processing and Human Diseases
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.25967
Abstract: N6‐methyladenosine (m6A) modification is an abundant and conservative RNA modification in bacterial and eukaryotic cells. m6A modification mainly occurs in the 3′ untranslated regions (UTRs) and near the stop codons of mRNA. Diverse strategies have… read more here.
Keywords: methyladenosine m6a; m6a modification; rna processing; m6a ... See more keywords
ALKBH5 gene polymorphisms and Wilms tumor risk in Chinese children: A five‐center case‐control study
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Clinical Laboratory Analysis"
DOI: 10.1002/jcla.23251
Abstract: Wilms tumor is a frequently diagnosed renal cancer among children with unclear genetic causes. N6‐methyladenosine (m6A) modification genes play critical roles in tumorigenesis. However, whether genetic variations of m6A modification genes predispose to Wilms tumor… read more here.
Keywords: m6a modification; gene polymorphisms; alkbh5 gene; wilms tumor ... See more keywords
N6‐methyladenosine modification participates in neoplastic immunoregulation and tumorigenesis
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.30730
Abstract: This review aims to provide insight into the role of N6‐methyladenosine (m6A) modification in neoplastic immunity and subsequent tumorigenesis. m6A modification, which is catalyzed by methyltransferases, demethylases and reader proteins, has emerged as a widespread… read more here.
Keywords: modification participates; modification; m6a modification; tumorigenesis ... See more keywords
The emerging roles of the interaction between m6A modification and c‐Myc in driving tumorigenesis and development
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.30733
Abstract: N6‐methyladenosine (m6A) is an extremely common and conservative posttranscriptional modification, that can specifically target and regulate the expression or stability of a series of tumor‐related genes, thus playing critical roles in the occurrence and development… read more here.
Keywords: modification; m6a modification; development; modification myc ... See more keywords
Structural and functional characterization of TrmM in m6A modification of bacterial tRNA
Sign Up to like & getrecommendations! Published in 2022 at "Protein Science"
DOI: 10.1002/pro.4319
Abstract: N6‐methyladenosine (m6A), widely distributed in both coding and noncoding RNAs, regulates the epigenetic signals and RNA metabolism in eukaryotes. Although this posttranscriptional modification is frequently observed in messenger and ribosomal RNA, it is relatively rare… read more here.
Keywords: modification; m6a modification; trna; trmm ... See more keywords
Dot Blot Analysis for Measuring Global N6-Methyladenosine Modification of RNA.
Sign Up to like & getrecommendations! Published in 2019 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-8808-2_20
Abstract: Posttranscriptional modification of mRNAs plays an important role in establishing the functional diversity of the proteome. The m6A modification is found in many species of RNA, including tRNA, mRNA, rRNA, and long noncoding RNAs. The physiological role… read more here.
Keywords: dot blot; modification; m6a modification; m6a ... See more keywords
RNA N 6-Methyladenosine Modification in Normal and Malignant Hematopoiesis.
Sign Up to like & getrecommendations! Published in 2019 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-981-13-7342-8_4
Abstract: As the most abundant internal modification in eukaryotic messenger RNAs (mRNAs), N 6-methyladenosine (m6A) modification has been shown recently to posttranscriptionally regulate expression of thousands of messenger RNA (mRNA) transcripts in each mammalian cell type… read more here.
Keywords: hematopoiesis; m6a modification; rna methyladenosine; methyladenosine modification ... See more keywords
Mettl3 inhibits the apoptosis and autophagy of chondrocytes in inflammation through mediating Bcl2 stability via Ythdf1-mediated m6A modification.
Sign Up to like & getrecommendations! Published in 2021 at "Bone"
DOI: 10.1016/j.bone.2021.116182
Abstract: N6-methyladenosine (m6A) methylation is one of the most common internal modifications in eukaryotic messenger RNA occurring on N6 nitrogen of adenosine. However, the roles of m6A in temporomandibular joint osteoarthritis (TMJ OA) are still elusive.… read more here.
Keywords: m6a modification; mettl3; apoptosis autophagy; autophagy chondrocytes ... See more keywords
Increased m6A RNA modification is related to the inhibition of the Nrf2-mediated antioxidant response in di-(2-ethylhexyl) phthalate-induced prepubertal testicular injury.
Sign Up to like & getrecommendations! Published in 2020 at "Environmental pollution"
DOI: 10.1016/j.envpol.2020.113911
Abstract: Di-(2-ethylhexyl) phthalate (DEHP) is a common environmental endocrine disrupting chemical that may induce male reproductive disorders. Exposure to DEHP at a prepubertal stage could lead to prepubertal testicular injury, but the underlying mechanisms remain unclear.… read more here.
Keywords: prepubertal testicular; m6a modification; testicular injury; ethylhexyl phthalate ... See more keywords