Transcriptome-wide analysis of glioma stem cell specific m6A modifications in long-non-coding RNAs
Sign Up to like & getrecommendations! Published in 2022 at "Scientific Reports"
DOI: 10.1038/s41598-022-08616-z
Abstract: The interest in chemical RNA modifications is rapidly growing in the field of molecular biology. Dynamic and reversible alterations of N6-methyladenosine (m6A) RNA modification are responsible for a platter of structural and functional changes in… read more here.
Keywords: analysis; m6a; specific m6a; non coding ... See more keywords
Inhibition of METTL3 attenuates renal injury and inflammation by alleviating TAB3 m6A modifications via IGF2BP2-dependent mechanisms
Sign Up to like & getrecommendations! Published in 2022 at "Science Translational Medicine"
DOI: 10.1126/scitranslmed.abk2709
Abstract: The role of N6-methyladenosine (m6A) modifications in renal diseases is largely unknown. Here, we characterized the role of N6-adenosine-methyltransferase-like 3 (METTL3), whose expression is elevated in renal tubules in different acute kidney injury (AKI) models… read more here.
Keywords: renal injury; m6a modifications; injury inflammation; mettl3 ... See more keywords
m6A Modification Mediates Endothelial Cell Responses to Oxidative Stress in Vascular Aging Induced by Low Fluid Shear Stress
Sign Up to like & getrecommendations! Published in 2023 at "Oxidative Medicine and Cellular Longevity"
DOI: 10.1155/2023/8134027
Abstract: N6-methyladenosine (m6A) is one of the most prevalent, abundant, and internal transcriptional modification and plays essential roles in diverse cellular and physiological processes. Low fluid shear stress (FSS) is a key pathological factor for many… read more here.
Keywords: stress; modification; m6a modifications; oxidative stress ... See more keywords
RNA m6A modifications in mammalian gametogenesis and pregnancy.
Sign Up to like & getrecommendations! Published in 2022 at "Reproduction"
DOI: 10.1530/rep-22-0112
Abstract: The epitranscriptome is defined as the collection of post-transcriptional chemical modifications of RNA in a cell. RNA methylation refers to the chemical post-transcriptional modification of RNA by selectively adding methyl groups under the catalysis of… read more here.
Keywords: m6a modifications; gametogenesis; rna; rna m6a ... See more keywords
Molecular Characterization of m6A Modifications in Non-Clear Cell Renal Cell Carcinoma and Potential Relationship with Pathological Types
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DOI: 10.2147/ijgm.s348343
Abstract: Background N6-Methyladenosine (m6A) modification is a eukaryotic mRNA modification that modulates the fate of modified RNA and, therefore, the expression of proteins. m6A modifications are associated with important roles in several cancers. Most studies related… read more here.
Keywords: cell carcinoma; cell; non ccrcc; m6a modifications ... See more keywords
N6-methyladenosine modifications in maternal-fetal crosstalk and gestational diseases
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2023.1164706
Abstract: As a medium among pregnant women, environment and fetus, placenta owns powerful and delicate epigenetic processes to regulate gene expression and maintain cellular homeostasis. N6-methyladenosine (m6A) is the most prevalent modification that determines the fate… read more here.
Keywords: gestational diseases; m6a modifications; maternal fetal; modifications maternal ... See more keywords
Hypericin Ameliorates Depression-like Behaviors via Neurotrophin Signaling Pathway Mediating m6A Epitranscriptome Modification
Sign Up to like & getrecommendations! Published in 2023 at "Molecules"
DOI: 10.3390/molecules28093859
Abstract: Hypericin, one of the major antidepressant constituents of St. John’s wort, was shown to exert antidepressant effects by affecting cerebral CYP enzymes, serotonin homeostasis, and neuroinflammatory signaling pathways. However, its exact mechanisms are unknown. Previous… read more here.
Keywords: modification; m6a modifications; signaling pathway; neurotrophin signaling ... See more keywords