A Unified Model for the Function of YTHDF Proteins in Regulating m6A-Modified mRNA
Sign Up to like & getrecommendations! Published in 2020 at "Cell"
DOI: 10.1016/j.cell.2020.05.012
Abstract: N6-methyladenosine (m6A) is the most abundant mRNA nucleotide modification and regulates critical aspects of cellular physiology and differentiation. m6A is thought to mediate its effects through a complex network of interactions between different m6A sites… read more here.
Keywords: ythdf proteins; m6a modified; unified model; m6a ... See more keywords
Changes and relationship of N6-methyladenosine modification and Long non-coding RNAs in oxidative damage induced by cadmium in pancreatic β-cells.
Sign Up to like & getrecommendations! Published in 2021 at "Toxicology letters"
DOI: 10.1016/j.toxlet.2021.02.014
Abstract: N6-methyladenosine (m6A) modification and m6A-modified Long non-coding RNAs (LncRNAs) play crucial roles in various pathological processes, yet their changes and relationship in cadmium-induced oxidative damage are largely unknown. Here, five m6A-modified LncRNAs (LncRNA-TUG1, LncRNA-PVT1, LncRNA-MALAT1,… read more here.
Keywords: m6a modification; oxidative damage; m6a modified; modification ... See more keywords
Identification of N6-methyladenosine reader proteins.
Sign Up to like & getrecommendations! Published in 2017 at "Methods"
DOI: 10.1016/j.ymeth.2017.04.019
Abstract: The reversible N6-methyladenosine (m6A) modification of eukaryotic messenger RNAs (mRNAs) is a widespread regulatory mechanism that impacts every step in the mRNA life cycle. The effect of m6A on mRNA fate depends on the binding… read more here.
Keywords: reader proteins; reader; methyladenosine; m6a reader ... See more keywords
YTHDF3 facilitates translation and decay of N6-methyladenosine-modified RNA
Sign Up to like & getrecommendations! Published in 2017 at "Cell Research"
DOI: 10.1038/cr.2017.15
Abstract: N6-methyladenosine (m6A) is the most abundant internal modification in eukaryotic messenger RNAs (mRNAs), and plays important roles in cell differentiation and tissue development. It regulates multiple steps throughout the RNA life cycle including RNA processing,… read more here.
Keywords: translation decay; ythdf3; m6a modified; translation ... See more keywords
Interferon-stimulated gene 20 (ISG20) selectively degrades N6-methyladenosine modified Hepatitis B Virus transcripts
Sign Up to like & getrecommendations! Published in 2020 at "PLoS Pathogens"
DOI: 10.1371/journal.ppat.1008338
Abstract: Interferon (IFN) stimulates a whole repertoire of cellular genes, collectively referred to as ISGs (Interferon-stimulated genes). ISG20, a 3´-5´ exonuclease enzyme, has been previously shown to bind and degrade hepatitis B Virus (HBV) transcripts. Here,… read more here.
Keywords: hbv transcripts; rna; m6a modified; hepatitis virus ... See more keywords
The m6A methyltransferase METTL3 aggravates the progression of nasopharyngeal carcinoma through inducing EMT by m6A-modified Snail mRNA.
Sign Up to like & getrecommendations! Published in 2020 at "Minerva medica"
DOI: 10.23736/s0026-4806.20.06653-7
Abstract: BACKGROUND This study aims to elucidate the role of METTL3 in aggravating the progression of NPC through m6A modification on Snail and thus the stimulated EMT (epithelial-mesenchymal transition). PATIENTS AND METHODS Differential expressions of METTL3… read more here.
Keywords: knockdown mettl3; mettl3; m6a modified; snail ... See more keywords
Transcriptome-Wide m6A Methylome and m6A-Modified Gene Analysis in Asthma
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2022.799459
Abstract: N6-methyladenosine (m6A) modification is one of the most prevalent RNA modification forms and is an important posttranscriptional mechanism for regulating genes. In previous research, we found that m6A regulator–mediated RNA methylation modification was involved in… read more here.
Keywords: modification; m6a modified; wide m6a; transcriptome wide ... See more keywords
The Important Role of m6A-Modified circRNAs in the Differentiation of Intramuscular Adipocytes in Goats Based on MeRIP Sequencing Analysis
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24054817
Abstract: Intramuscular fat contributes to the improvement of goat meat quality. N6-Methyladenosine (m6A)-modified circular RNAs play important roles in adipocyte differentiation and metabolism. However, the mechanisms by which m6A modifies circRNA before and after differentiation of… read more here.
Keywords: circrna; m6a modified; intramuscular adipocytes; differentiation ... See more keywords
Novel insight into the functions of N6-methyladenosine modified lncRNAs in cancers (Review)
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Oncology"
DOI: 10.3892/ijo.2022.5442
Abstract: Emerging evidence has suggested that N6-methyladenosine (m6A) modification, a typical RNA methylation modification, controls the fate of modified transcripts and is involved in the pathogenesis of various human diseases, such as metabolic disorders, nephropathology, osteoarthritis… read more here.
Keywords: m6a modified; novel insight; insight functions; modified lncrnas ... See more keywords
M6A-modified circRBM33 promotes prostate cancer progression via PDHA1-mediated mitochondrial respiration regulation and presents a potential target for ARSI therapy
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Biological Sciences"
DOI: 10.7150/ijbs.77133
Abstract: N6-Methyladenosine (m6A) is the most prevalent RNA modification in various types of RNA, including circular RNAs (circRNAs). Mounting evidence has shown that circRNAs may play critical roles in diverse malignancies. However, the biological relevance of… read more here.
Keywords: m6a modified; prostate cancer; circrbm33; arsi therapy ... See more keywords