m6A‐modified EHD1 controls PD‐L1 endosomal trafficking to modulate immune evasion and immunotherapy responses in lung adenocarcinoma
Sign Up to like & getrecommendations! Published in 2025 at "Cancer Communications"
DOI: 10.1002/cac2.70052
Abstract: Eps15 homology domain (EHD) proteins, including EHD1 to EHD4, play vital roles in tumor progression. In this study, we aimed to investigate which specific EHD proteins, if any, are implicated in tumor immune evasion and… read more here.
Keywords: m6a modified; immune evasion; evasion immunotherapy;
Integrated analysis of differentially m6A modified and expressed lncRNAs for biomarker identification in coronary artery disease
Sign Up to like & getrecommendations! Published in 2024 at "Cell Biology International"
DOI: 10.1002/cbin.12224
Abstract: N6‐methyladenosine (m6A) is the most prevalent internal RNA modification in mammals. However, limited research has been conducted on the role of m6A in coronary artery disease (CAD). We conducted methylated RNA immunoprecipitation sequencing and RNA… read more here.
Keywords: coronary artery; modified expressed; differentially m6a; artery disease ... See more keywords
A Unified Model for the Function of YTHDF Proteins in Regulating m6A-Modified mRNA
Sign Up to like & getrecommendations! Published in 2020 at "Cell"
DOI: 10.1016/j.cell.2020.05.012
Abstract: N6-methyladenosine (m6A) is the most abundant mRNA nucleotide modification and regulates critical aspects of cellular physiology and differentiation. m6A is thought to mediate its effects through a complex network of interactions between different m6A sites… read more here.
Keywords: ythdf proteins; m6a modified; unified model; m6a ... See more keywords
Changes and relationship of N6-methyladenosine modification and Long non-coding RNAs in oxidative damage induced by cadmium in pancreatic β-cells.
Sign Up to like & getrecommendations! Published in 2021 at "Toxicology letters"
DOI: 10.1016/j.toxlet.2021.02.014
Abstract: N6-methyladenosine (m6A) modification and m6A-modified Long non-coding RNAs (LncRNAs) play crucial roles in various pathological processes, yet their changes and relationship in cadmium-induced oxidative damage are largely unknown. Here, five m6A-modified LncRNAs (LncRNA-TUG1, LncRNA-PVT1, LncRNA-MALAT1,… read more here.
Keywords: m6a modification; oxidative damage; m6a modified; modification ... See more keywords
Identification of N6-methyladenosine reader proteins.
Sign Up to like & getrecommendations! Published in 2017 at "Methods"
DOI: 10.1016/j.ymeth.2017.04.019
Abstract: The reversible N6-methyladenosine (m6A) modification of eukaryotic messenger RNAs (mRNAs) is a widespread regulatory mechanism that impacts every step in the mRNA life cycle. The effect of m6A on mRNA fate depends on the binding… read more here.
Keywords: reader proteins; reader; methyladenosine; m6a reader ... See more keywords
Spatial Mapping and Interactome Profiling of m6A-Modified R-Loops via Chemically Inducible Split-APEX2 Proximity Labeling.
Sign Up to like & getrecommendations! Published in 2025 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.5c05501
Abstract: m6A-Modified R-loops (m6A-R-loops) play crucial roles in epigenetic regulation and genome stability, yet resolving their spatial distribution and protein interactomes in live cells remains challenging. To address this, we developed m6A-R-loop proximity labeling (m6A-RLPL), a… read more here.
Keywords: m6a; proximity labeling; chemically inducible; proximity ... See more keywords
YTHDF3 facilitates translation and decay of N6-methyladenosine-modified RNA
Sign Up to like & getrecommendations! Published in 2017 at "Cell Research"
DOI: 10.1038/cr.2017.15
Abstract: N6-methyladenosine (m6A) is the most abundant internal modification in eukaryotic messenger RNAs (mRNAs), and plays important roles in cell differentiation and tissue development. It regulates multiple steps throughout the RNA life cycle including RNA processing,… read more here.
Keywords: translation decay; ythdf3; m6a modified; translation ... See more keywords
m6A-modified circXPO1 accelerates colorectal cancer progression via interaction with FMRP to promote WWC2 mRNA decay
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Translational Medicine"
DOI: 10.1186/s12967-024-05716-4
Abstract: Recent evidence has demonstrated the vital roles of circular RNAs (circRNAs) in the progression of colorectal cancer (CRC); however, their functions and mechanisms in CRC need to be further explored. This study aimed to uncover… read more here.
Keywords: colorectal cancer; crc; progression; circxpo1 ... See more keywords
Interferon-stimulated gene 20 (ISG20) selectively degrades N6-methyladenosine modified Hepatitis B Virus transcripts
Sign Up to like & getrecommendations! Published in 2020 at "PLoS Pathogens"
DOI: 10.1371/journal.ppat.1008338
Abstract: Interferon (IFN) stimulates a whole repertoire of cellular genes, collectively referred to as ISGs (Interferon-stimulated genes). ISG20, a 3´-5´ exonuclease enzyme, has been previously shown to bind and degrade hepatitis B Virus (HBV) transcripts. Here,… read more here.
Keywords: hbv transcripts; rna; m6a modified; hepatitis virus ... See more keywords
The m6A methyltransferase METTL3 aggravates the progression of nasopharyngeal carcinoma through inducing EMT by m6A-modified Snail mRNA.
Sign Up to like & getrecommendations! Published in 2020 at "Minerva medica"
DOI: 10.23736/s0026-4806.20.06653-7
Abstract: BACKGROUND This study aims to elucidate the role of METTL3 in aggravating the progression of NPC through m6A modification on Snail and thus the stimulated EMT (epithelial-mesenchymal transition). PATIENTS AND METHODS Differential expressions of METTL3… read more here.
Keywords: knockdown mettl3; mettl3; m6a modified; snail ... See more keywords
Transcriptome-Wide m6A Methylome and m6A-Modified Gene Analysis in Asthma
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2022.799459
Abstract: N6-methyladenosine (m6A) modification is one of the most prevalent RNA modification forms and is an important posttranscriptional mechanism for regulating genes. In previous research, we found that m6A regulator–mediated RNA methylation modification was involved in… read more here.
Keywords: modification; m6a modified; wide m6a; transcriptome wide ... See more keywords