Comment on: The m6A Reader IGF2BP2 Regulates Macrophage Phenotypic Activation and Inflammatory Diseases by Stabilizing TSC1 and PPARγ
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Science"
DOI: 10.1002/advs.202104372
Abstract: Recently, first insights into the regulation and the role of the RNA‐binding protein IMP2 in macrophage activation have been published by Wang et al. This study addresses differences in the regulation of IMP2 between the… read more here.
Keywords: inflammatory; reader igf2bp2; igf2bp2 regulates; m6a reader ... See more keywords
The m6A reader YTHDC2 inhibits lung adenocarcinoma tumorigenesis by suppressing SLC7A11-dependent antioxidant function
Sign Up to like & getrecommendations! Published in 2020 at "Redox Biology"
DOI: 10.1016/j.redox.2020.101801
Abstract: The biological functions of N6-methyladenosine (m6A) RNA methylation are mainly dependent on the reader; however, its role in lung tumorigenesis remains unclear. Here, we have demonstrated that the m6A reader YT521-B homology domain containing 2… read more here.
Keywords: ythdc2; tumorigenesis; luad; m6a reader ... See more keywords
Identification of N6-methyladenosine reader proteins.
Sign Up to like & getrecommendations! Published in 2017 at "Methods"
DOI: 10.1016/j.ymeth.2017.04.019
Abstract: The reversible N6-methyladenosine (m6A) modification of eukaryotic messenger RNAs (mRNAs) is a widespread regulatory mechanism that impacts every step in the mRNA life cycle. The effect of m6A on mRNA fate depends on the binding… read more here.
Keywords: reader proteins; reader; methyladenosine; m6a reader ... See more keywords
Targeted m6A Reader Proteins To Study Epitranscriptomic Regulation of Single RNAs.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.8b05012
Abstract: Post-transcriptional gene expression regulation of RNA has emerged as a key factor that controls mammalian protein production. RNA trafficking, translation efficiency, and stability are all controlled at the transcript level. For example, in addition to… read more here.
Keywords: reader proteins; targeted m6a; reader; rna ... See more keywords
A novel m6A reader Prrc2a controls oligodendroglial specification and myelination
Sign Up to like & getrecommendations! Published in 2018 at "Cell Research"
DOI: 10.1038/s41422-018-0113-8
Abstract: While N6-methyladenosine (m6A), the most abundant internal modification in eukaryotic mRNA, is linked to cell differentiation and tissue development, the biological significance of m6A modification in mammalian glial development remains unknown. Here, we identify a… read more here.
Keywords: prrc2a; novel m6a; m6a reader; m6a ... See more keywords
m6A in mRNA coding regions promotes translation via the RNA helicase-containing YTHDC2
Sign Up to like & getrecommendations! Published in 2019 at "Nature Communications"
DOI: 10.1038/s41467-019-13317-9
Abstract: Dynamic mRNA modification in the form of N 6 -methyladenosine (m6A) adds considerable richness and sophistication to gene regulation. The m6A mark is asymmetrically distributed along mature mRNAs, with approximately 35% of m6A residues located… read more here.
Keywords: rna helicase; cds m6a; translation; m6a reader ... See more keywords
m6A reader YTHDC1 modulates autophagy by targeting SQSTM1 in diabetic skin.
Sign Up to like & getrecommendations! Published in 2021 at "Autophagy"
DOI: 10.1080/15548627.2021.1974175
Abstract: Dysregulation of macroautophagy/autophagy contributes to the delay of wound healing in diabetic skin. N6-methyladenosine (m6A) RNA modification is known to play a critical role in regulating autophagy. In this study, it was found that SQSTM1/p62… read more here.
Keywords: protein; diabetic skin; rna; autophagy ... See more keywords
Epitranscriptomic Turbo for Autophagy Boost: m6A reader YTHDF3.
Sign Up to like & getrecommendations! Published in 2022 at "Autophagy"
DOI: 10.1080/15548627.2022.2146890
Abstract: Mcroautophagy/autophagy plays an important role in maintaining homeostasis during nutrient starvation. However, whether epitranscriptomic events are involved in this process remains unclear. Our recent findings suggest that m6A reader YTHDF3 has an essential role in… read more here.
Keywords: m6a reader; reader ythdf3; autophagy;
Nuclear m6A reader YTHDC1 promotes muscle stem cell activation/proliferation by regulating mRNA splicing and nuclear export
Sign Up to like & getrecommendations! Published in 2022 at "eLife"
DOI: 10.1101/2022.08.07.503064
Abstract: Skeletal muscle stem cells (also known as satellite cells, SCs) are essential for muscle regeneration and the regenerative activities of SCs are intrinsically governed by gene regulatory mechanisms but the post-transcriptional regulation in SCs remains… read more here.
Keywords: m6a reader; nuclear export; export; activation proliferation ... See more keywords
Downregulation of m6A reader YTHDC2 promotes tumor progression and predicts poor prognosis in non‐small cell lung cancer
Sign Up to like & getrecommendations! Published in 2020 at "Thoracic Cancer"
DOI: 10.1111/1759-7714.13667
Abstract: m6A modification affects the pathological progress of many diseases by affecting RNA stability and translocation. YTHDC2, a m6A reader, is associated with multiple cancers; however, little is known of its role in non‐small cell lung… read more here.
Keywords: lung cancer; cell lung; m6a reader; non small ... See more keywords
The RNA m6A reader YTHDF2 maintains oncogene expression and is a targetable dependency in glioblastoma stem cells.
Sign Up to like & getrecommendations! Published in 2020 at "Cancer discovery"
DOI: 10.1158/2159-8290.cd-20-0331
Abstract: Glioblastoma is a universally lethal cancer driven by glioblastoma stem cells (GSCs). Here, we interrogated N6-methyladenosine (m6A) mRNA modifications in GSCs by methyl RNA-immunoprecipitation followed by sequencing (meRIP-seq) and transcriptome analysis, finding transcripts marked by… read more here.
Keywords: glioblastoma; m6a reader; stem cells; ythdf2 ... See more keywords