An additional class of m6A readers
Sign Up to like & getrecommendations! Published in 2018 at "Nature Cell Biology"
DOI: 10.1038/s41556-018-0046-y
Abstract: N6-methyladenosine (m6A) mRNA modification influences mRNA fate by stimulating recruitment of m6A reader proteins. A previously unappreciated class of m6A reader proteins is now shown to use a common RNA-binding domain and flanking regions to… read more here.
Keywords: additional class; m6a readers; class m6a; m6a ... See more keywords
Enterovirus 2Apro Cleavage of the YTHDF m6A Readers Implicates YTHDF3 as a Mediator of Type I Interferon-Driven JAK/STAT Signaling
Sign Up to like & getrecommendations! Published in 2021 at "mBio"
DOI: 10.1128/mbio.00116-21
Abstract: It is believed that ∼7,000 messenger RNAs (mRNAs) are subject to N6-methyladenosine modification. The biological significance of this remains mysterious. ABSTRACT Enteroviruses (EV) deploy two proteases that mediate viral polyprotein cleavage and host cell manipulation.… read more here.
Keywords: cleavage; stat signaling; m6a readers; m6a ... See more keywords
m6A readers, writers, erasers, and the m6A epitranscriptome in breast cancer.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of molecular endocrinology"
DOI: 10.1530/jme-22-0110
Abstract: Epitranscriptomic modification of RNA regulates human development, health, and disease. The true diversity of the transcriptome in breast cancer including chemical modification of transcribed RNA (epitranscriptomics) is not well understood due to limitations of technology… read more here.
Keywords: breast cancer; cancer; m6a readers; erasers m6a ... See more keywords
Identification of Two m6A Readers YTHDF1 and IGF2BP2 as Immune Biomarkers in Head and Neck Squamous Cell Carcinoma
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2022.903634
Abstract: Background: N6-methyladenosine (m6A) is the most abundant internal modification pattern in mammals that a plays critical role in tumorigenesis and immune regulations. However, the effect of m6A modification on head and neck squamous cell carcinoma… read more here.
Keywords: cell; readers ythdf1; m6a readers; ythdf1 igf2bp2 ... See more keywords