Discovery of substituted indole derivatives as allosteric inhibitors of m6A‐RNA methyltransferase, METTL3‐14 complex
Sign Up to like & getrecommendations! Published in 2022 at "Drug Development Research"
DOI: 10.1002/ddr.21910
Abstract: m6A RNA methyltransferase (METTL3‐14) catalyzes the methylation of adenosine in mRNA and plays important roles in mRNA functions, and it has been implicated in the progression of multiple cancers, including acute myeloid leukemia (AML). In… read more here.
Keywords: m6a rna; mettl3 complex; rna methyltransferase; methyltransferase mettl3 ... See more keywords
A role for m6A RNA methylation in heart failure development?
Sign Up to like & getrecommendations! Published in 2019 at "European Journal of Heart Failure"
DOI: 10.1002/ejhf.1714
Abstract: Heart failure persists as a significant cause of death and low quality of life. It is a major public health issue of which the prevalence continues to rise. In industrialized countries, heart failure affects near… read more here.
Keywords: heart; heart failure; m6a rna; development ... See more keywords
Comprehensive Analysis of Differential m6A RNA Methylomes in the Hippocampus of Cocaine-Conditioned Mice.
Sign Up to like & getrecommendations! Published in 2021 at "Molecular neurobiology"
DOI: 10.1007/s12035-021-02363-4
Abstract: N6-methyladenosine (m6A) is the most prevalent internal modification found in mRNAs and lncRNA and plays a vital role in posttranscriptional regulation in mammals. m6A is abundant in the nervous system, where it modulates neuronal development… read more here.
Keywords: m6a peaks; hippocampus cocaine; m6a; cocaine ... See more keywords
m6A RNA methylation regulates promoter- proximal pausing of RNA polymerase II.
Sign Up to like & getrecommendations! Published in 2021 at "Molecular cell"
DOI: 10.1016/j.molcel.2021.06.023
Abstract: RNA polymerase II (RNAP II) pausing is essential to precisely control gene expression and is critical for development of metazoans. Here, we show that the m6A RNA modification regulates promoter-proximal RNAP II pausing in Drosophila… read more here.
Keywords: m6a rna; gene; rnap; rna polymerase ... See more keywords
Functional Dissection of the m6A RNA Modification.
Sign Up to like & getrecommendations! Published in 2017 at "Trends in biochemical sciences"
DOI: 10.1016/j.tibs.2016.12.004
Abstract: Much work over the past three decades has established that chemical modifications of DNA and histones are intimately linked with various facets of DNA metabolism, most notably transcription. In addition to chromatin components, RNA has… read more here.
Keywords: functional dissection; rna; rna modification; m6a ... See more keywords
Rational Design and Optimization of m6A-RNA Demethylase FTO Inhibitors as Anticancer Agents
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Medicinal Chemistry"
DOI: 10.1021/acs.jmedchem.1c02075
Abstract: Aberrant regulation of N6-methyladenosine (m6A) RNA modification has been implicated in the progression of multiple diseases, including cancer. Previously, we identified a small molecule inhibitor of the m6A demethylase fat mass- and obesity-associated protein (FTO),… read more here.
Keywords: m6a rna; demethylase; fto; m6a ... See more keywords
Accurate detection of m6A RNA modifications in native RNA sequences
Sign Up to like & getrecommendations! Published in 2019 at "Nature Communications"
DOI: 10.1038/s41467-019-11713-9
Abstract: The epitranscriptomics field has undergone an enormous expansion in the last few years; however, a major limitation is the lack of generic methods to map RNA modifications transcriptome-wide. Here, we show that using direct RNA… read more here.
Keywords: modifications native; rna; rna modifications; m6a rna ... See more keywords
m6A RNA methylation regulates the fate of endogenous retroviruses.
Sign Up to like & getrecommendations! Published in 2021 at "Nature"
DOI: 10.1038/s41586-020-03135-1
Abstract: Endogenous retroviruses (ERVs) are abundant and heterogenous groups of integrated retroviral sequences that affect genome regulation and cell physiology throughout their RNA-centred life cycle1. Failure to repress ERVs is associated with cancer, infertility, senescence and… read more here.
Keywords: rna methylation; methylation; endogenous retroviruses; mettl3 mettl14 ... See more keywords
Construction and validation of m6A RNA methylation regulators associated prognostic model for gastrointestinal cancer
Sign Up to like & getrecommendations! Published in 2022 at "IET Systems Biology"
DOI: 10.1049/syb2.12040
Abstract: Abstract N6‐methyladenosine (m6A) RNA methylation is correlated with carcinogenesis and dynamically possessed through the m6A RNA methylation regulators. This paper aimed to explore 13 m6A RNA methylation regulators' role in gastrointestinal cancer (GIC) and determine… read more here.
Keywords: m6a rna; rna methylation; methylation regulators; model ... See more keywords
m6A RNA Modification Determines Cell Fate by Regulating mRNA Degradation.
Sign Up to like & getrecommendations! Published in 2017 at "Cellular reprogramming"
DOI: 10.1089/cell.2016.0041
Abstract: Emerging evidence suggests that epitranscriptional modifications influence multiple cellular processes. N6-methyladenosine (m6A), as the most abundant reversible methylation of mRNA, has also been reported to play critical roles in modulating embryonic stem cell differentiation and… read more here.
Keywords: m6a rna; mrna degradation; cell fate; m6a ... See more keywords
Funm6AViewer: a web server and R package for functional analysis of context-specific m6A RNA methylation.
Sign Up to like & getrecommendations! Published in 2021 at "Bioinformatics"
DOI: 10.1093/bioinformatics/btab362
Abstract: MOTIVATION N6-methyladenosine (m6A) is the most abundant mammalian mRNA methylation with versatile functions. To date, although a number of bioinformatics tools have been developed for location discovery of m6A modification, functional understanding is still quite… read more here.
Keywords: rna methylation; methylation; specific m6a; m6a ... See more keywords