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   Articles with "m6am" as a keyword



Differential m6A, m6Am, and m1A Demethylation Mediated by FTO in the Cell Nucleus and Cytoplasm.

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recommendations! Published in 2018 at "Molecular cell"

DOI: 10.1016/j.molcel.2018.08.011

Abstract: FTO, the first RNA demethylase discovered, mediates the demethylation of internal N6-methyladenosine (m6A) and N6, 2-O-dimethyladenosine (m6Am) at the +1 position from the 5' cap in mRNA. Here we demonstrate that the cellular distribution of FTO… read more here.

Keywords: m6am; demethylation; m6a; cell ... See more keywords

Regulation of m6Am RNA modification and its implications in human diseases

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recommendations! Published in 2024 at "Journal of Molecular Cell Biology"

DOI: 10.1093/jmcb/mjae012

Abstract: Abstract N 6,2′-O-dimethyladenosine (m6Am) is a prevalent modification frequently found at the 5′ cap-adjacent adenosine of messenger RNAs (mRNAs) and small nuclear RNAs (snRNAs) and the internal adenosine of snRNAs. This dynamic and reversible modification… read more here.

Keywords: m6am rna; m6am; rna modification; human diseases ... See more keywords

Cap-specific terminal N6-methylation of RNA by an RNA polymerase II–associated methyltransferase

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recommendations! Published in 2019 at "Science"

DOI: 10.1126/science.aav0080

Abstract: A cap-specific m6A writer N6,2′-O-dimethyladenosine (m6Am) is present at the transcription start nucleotide of capped mRNAs in vertebrates. Akichika et al. quantified the abundance of this modification in the transcriptome and identified the writer protein,… read more here.

Keywords: methylation; capped mrnas; m6am; cap specific ... See more keywords

m6Aminer: Predicting the m6Am Sites on mRNA by Fusing Multiple Sequence-Derived Features into a CatBoost-Based Classifier

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recommendations! Published in 2023 at "International Journal of Molecular Sciences"

DOI: 10.3390/ijms24097878

Abstract: As one of the most important post-transcriptional modifications, m6Am plays a fairly important role in conferring mRNA stability and in the progression of cancers. The accurate identification of the m6Am sites is critical for explaining… read more here.

Keywords: catboost based; sites mrna; m6am; feature ... See more keywords

Decoding m6Am by simultaneous transcription-start mapping and methylation quantification

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recommendations! Published in 2025 at "eLife"

DOI: 10.7554/elife.104139

Abstract: N 6,2’-O-dimethyladenosine (m6Am) is a modified nucleotide located at the first transcribed position in mRNA and snRNA that is essential for diverse physiological processes. m6Am mapping methods assume each gene uses a single start nucleotide.… read more here.

Keywords: transcription start; start; m6am simultaneous; m6am ... See more keywords