Differential m6A, m6Am, and m1A Demethylation Mediated by FTO in the Cell Nucleus and Cytoplasm.
Sign Up to like & getrecommendations! Published in 2018 at "Molecular cell"
DOI: 10.1016/j.molcel.2018.08.011
Abstract: FTO, the first RNA demethylase discovered, mediates the demethylation of internal N6-methyladenosine (m6A) and N6, 2-O-dimethyladenosine (m6Am) at the +1 position from the 5' cap in mRNA. Here we demonstrate that the cellular distribution of FTO… read more here.
Keywords: m6am; demethylation; m6a; cell ... See more keywords
Cap-specific terminal N6-methylation of RNA by an RNA polymerase II–associated methyltransferase
Sign Up to like & getrecommendations! Published in 2019 at "Science"
DOI: 10.1126/science.aav0080
Abstract: A cap-specific m6A writer N6,2′-O-dimethyladenosine (m6Am) is present at the transcription start nucleotide of capped mRNAs in vertebrates. Akichika et al. quantified the abundance of this modification in the transcriptome and identified the writer protein,… read more here.
Keywords: methylation; capped mrnas; m6am; cap specific ... See more keywords
m6Aminer: Predicting the m6Am Sites on mRNA by Fusing Multiple Sequence-Derived Features into a CatBoost-Based Classifier
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24097878
Abstract: As one of the most important post-transcriptional modifications, m6Am plays a fairly important role in conferring mRNA stability and in the progression of cancers. The accurate identification of the m6Am sites is critical for explaining… read more here.
Keywords: catboost based; sites mrna; m6am; feature ... See more keywords