Mannose-6-phosphate glycan for lysosomal targeting: various applications from enzyme replacement therapy to lysosome-targeting chimeras
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DOI: 10.1080/19768354.2022.2079719
Abstract: ABSTRACT A lysosome, an acidic membrane-bound organelle, contains hydrolytic enzymes to digest macromolecules for recycling. Many lysosomal enzymes (LEs) traffic to the lysosome through the mannose-6-phosphate (M6P)-dependent pathway. Some mannose residues of high-mannose type N-glycans… read more here.
Keywords: mannose phosphate; replacement therapy; lysosome; enzyme replacement ... See more keywords