Identifying N7-methylguanosine sites by integrating multiple features.
Sign Up to like & getrecommendations! Published in 2021 at "Biopolymers"
DOI: 10.1002/bip.23480
Abstract: Recent studies reported that N7-methylguanosine (m7G) plays a vital role in gene expression regulation. As a consequence, determining the distribution of m7G is a crucial step towards further understanding its biological functions. Although biological experimental… read more here.
Keywords: m7g; identifying methylguanosine; integrating multiple; methylguanosine sites ... See more keywords
METTL1 promotes cadmium-induced stress granules formation via enhancing translation of G3BP1 and expression of m7G- 3' tiRNA MetCAT
Sign Up to like & getrecommendations! Published in 2025 at "Cell Biology and Toxicology"
DOI: 10.1007/s10565-025-10072-0
Abstract: Methyltransferase 1 (METTL1) is currently regarded as a key tRNA m7G writer. Recent studies indicate its potential role in carcinogenesis via increased m7G modification to stabilize tRNA and upregulate tRNA expression. Cadmium-induced stress triggers the… read more here.
Keywords: m7g; mettl1; expression; cadmium induced ... See more keywords
Existence of Internal N7-Methylguanosine Modification in mRNA Determined by Differential Enzyme Treatment Coupled with Mass Spectrometry Analysis.
Sign Up to like & getrecommendations! Published in 2018 at "ACS chemical biology"
DOI: 10.1021/acschembio.7b00906
Abstract: The recent discovery of reversible chemical modifications on mRNA has opened a new era of post-transcriptional gene regulation in eukaryotes. Among the 15 types of modifications identified in mRNA of eukaryotes, N7-methylguanosine (m7G) is unique… read more here.
Keywords: spectrometry analysis; internal m7g; m7g; mass spectrometry ... See more keywords
IGF2BP3 promotes mRNA degradation through internal m7G modification
Sign Up to like & getrecommendations! Published in 2024 at "Nature Communications"
DOI: 10.1038/s41467-024-51634-w
Abstract: Recent studies have suggested that mRNA internal m7G and its writer protein METTL1 are closely related to cell metabolism and cancer regulation. Here, we identify that IGF2BP family proteins IGF2BP1-3 can preferentially bind internal mRNA… read more here.
Keywords: cancer; m7g; degradation; m7g modification ... See more keywords
N7-methylguanosine (m7G) tRNA modification: a novel autophagy modulator in cancer
Sign Up to like & getrecommendations! Published in 2022 at "Autophagy"
DOI: 10.1080/15548627.2022.2077551
Abstract: ABSTRACT Macroautophagy/autophagy, a physiological process that is involved in tumorigenesis, is regulated at genetic and epigenetic levels. Emerging reports suggest that aberrant RNA modifications cause dysregulated autophagy and affect tumorigenesis, while the role of RNA… read more here.
Keywords: modification; mettl1 wdr4; m7g trna; methylguanosine m7g ... See more keywords
Integrated analysis of bulk RNA and single-cell RNA sequencing data reveals potential biomarkers and immune infiltrates associated with N7-methylguanosine in osteoarthritis.
Sign Up to like & getrecommendations! Published in 2025 at "International journal of surgery"
DOI: 10.1097/js9.0000000000003571
Abstract: OBJECTIVE The N7-methylguanosine (m7G) modification is known as a common post-transcriptional modification of RNA that has been found to be involved in the pathogenesis of various diseases. However, its role in osteoarthritis (OA) remains largely… read more here.
Keywords: eif1 jund; m7g; analysis; risk ... See more keywords
Constructing and validating of m7G-related genes prognostic signature for hepatocellular carcinoma and immune infiltration: potential biomarkers for predicting the overall survival
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Gastrointestinal Oncology"
DOI: 10.21037/jgo-22-1134
Abstract: Background To investigate the prognostic significance of N7-methylguanosine (m7G) regulators and immune infiltration in liver hepatocellular carcinoma (LIHC). Methods The research measured predictive m7G genes in LIHC samples from The Cancer Genome Atlas (TCGA) and… read more here.
Keywords: oncology; m7g related; immune infiltration; related genes ... See more keywords
m7G Methyltransferase METTL1 Promotes Post-ischemic Angiogenesis via Promoting VEGFA mRNA Translation
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2021.642080
Abstract: Post-transcriptional modifications play pivotal roles in various pathological processes and ischemic disorders. However, the role of N7-methylguanosine (m7G), particularly m7G in mRNA, on post-ischemic angiogenesis remains largely unknown. Here, we identified that methyltransferase like 1… read more here.
Keywords: m7g; angiogenesis; post ischemic; ischemic angiogenesis ... See more keywords
Construction of m7G subtype classification on heterogeneity of sepsis
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2022.1021770
Abstract: Sepsis is a highly heterogeneous disease and a major factor in increasing mortality from infection. N7-Methylguanosine (m7G) is a widely RNA modification in eukaryotes, which involved in regulation of different biological processes. Researchers have found… read more here.
Keywords: sepsis; classification; heterogeneity sepsis; subtype ... See more keywords
Experimental verification and comprehensive analysis of m7G methylation regulators in the subcluster classification of ischemic stroke
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2022.1036345
Abstract: Background: Ischemic stroke (IS) is a fatal cerebrovascular disease involving several pathological mechanisms. Modification of 7-methylguanosine (m7G) has multiple regulatory functions. However, the expression pattern and mechanism of m7G in IS remain unknown. Herein, we… read more here.
Keywords: analysis; key m7g; ischemic stroke; m7g clusters ... See more keywords
A Novel M7G-Related MicroRNAs Risk Signature Predicts the Prognosis and Tumor Microenvironment of Kidney Renal Clear Cell Carcinoma
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2022.922358
Abstract: Background: M7G modification is extremely vital for the development of many cancers, especially tumor immunity. M7G modification is a novel functional regulator of miRNA, and the researches on m7G-related miRNAs in kidney renal clear cell… read more here.
Keywords: prognosis; signature; risk; risk signature ... See more keywords