Genome‐Scale CRISPR/Cas9 Screening Reveals Squalene Epoxidase as a Susceptibility Factor for Cytotoxicity of Malformin A1
Sign Up to like & getrecommendations! Published in 2019 at "Chembiochem"
DOI: 10.1002/cbic.201800769
Abstract: Malformin A1 (MA1) is a fungus‐produced cyclic pentapeptide. MA1 exhibits teratogenicity to plants, fibrinolysis‐enhancing activity, and cytotoxicity to mammalian cells. To clarify the cytotoxic mechanism of MA1, we screened for the genes involved in the cytotoxicity… read more here.
Keywords: crispr cas9; ma1; cytotoxicity; squalene epoxidase ... See more keywords
Malformin-A1 (MA1) Sensitizes Chemoresistant Ovarian Cancer Cells to Cisplatin-Induced Apoptosis
Sign Up to like & getrecommendations! Published in 2021 at "Molecules"
DOI: 10.3390/molecules26123624
Abstract: High-grade epithelial ovarian cancer is a fatal disease in women frequently associated with drug resistance and poor outcomes. We previously demonstrated that a marine-derived compound MalforminA1 (MA1) was cytotoxic for the breast cancer cell line… read more here.
Keywords: ovarian cancer; cancer cells; cancer; ma1 ... See more keywords