Punicalagin Enhances Autophagy Through Sirtuin 1/FoxO3a Axis to Inhibit Intracellular Mycobacterium Abscessus Infection.
Sign Up to like & getrecommendations! Published in 2025 at "Advanced science"
DOI: 10.1002/advs.202511734
Abstract: Mycobacterium abscessus (MAB) is an increasingly recognized rapidly growing nontuberculous mycobacterial pathogen whose infection is particularly challenging to treat due to its antibiotic resistance and persistence, necessitating the exploration of innovative treatment strategies. In this… read more here.
Keywords: punicalagin; mab; mycobacterium abscessus; infection ... See more keywords
Design of a microfluidic mixer channel: First steps into creating a fluorescent dye‐based biosensor for mAb aggregate detection
Sign Up to like & getrecommendations! Published in 2022 at "Biotechnology Journal"
DOI: 10.1002/biot.202200332
Abstract: A major challenge in the transition to continuous biomanufacturing is the lack of process analytical technology (PAT) tools which are able to collect real‐time information on the process and elicit a response to facilitate control.… read more here.
Keywords: mab; time; design; detection ... See more keywords
Glutathione and thioredoxin systems contribute to recombinant monoclonal antibody interchain disulfide bond reduction during bioprocessing
Sign Up to like & getrecommendations! Published in 2017 at "Biotechnology and Bioengineering"
DOI: 10.1002/bit.26278
Abstract: Antibody interchain disulfide bond reduction during biopharmaceutical manufacturing has received increased attention since it was first reported in 2010. Antibody reduction leads to loss of product and reduced product stability. It is therefore critical to… read more here.
Keywords: reduction; system; antibody; thioredoxin ... See more keywords
Application of a fluorescent dye-based microfluidic sensor for real-time detection of mAb aggregates.
Sign Up to like & getrecommendations! Published in 2023 at "Biotechnology progress"
DOI: 10.1002/btpr.3355
Abstract: The lack of process analytical technologies able to provide real-time information and process control over a biopharmaceutical process has long impaired the transition to continuous biomanufacturing. For the monoclonal antibody (mAb) production, aggregate formation is… read more here.
Keywords: mab; time; dye based; real time ... See more keywords
The Anti‐Human P2X7 Monoclonal Antibody (Clone L4) Can Mediate Complement‐Dependent Cytotoxicity of Human Leukocytes
Sign Up to like & getrecommendations! Published in 2025 at "European Journal of Immunology"
DOI: 10.1002/eji.202451196
Abstract: P2X7 is an extracellular adenosine 5′‐triphosphate (ATP)‐gated cation channel that plays various roles in inflammation and immunity. P2X7 is present on peripheral blood monocytes, dendritic cells (DCs), and innate and adaptive lymphocytes. The anti‐human P2X7… read more here.
Keywords: p2x7; anti human; p2x7 monoclonal; antibody ... See more keywords
Enhanced In Vivo Tetanus Toxin Neutralizing Potency of an Anti‐Toxin Monoclonal Antibody Following Antibody Chimerization
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Biochemical and Molecular Toxicology"
DOI: 10.1002/jbt.70595
Abstract: Each immunoglobulin molecule consists of two functional independent regions, including variable and constant regions. Toxin neutralization by antibody is mainly mediated by the variable regions. Here, we report that constant region chimerization of a mouse… read more here.
Keywords: antibody; tetanus toxin; mab; toxin neutralizing ... See more keywords
Discovery of Bimetallic Hexagonal MBene Mo2ErB3T2.5 (T = O, F, and Cl).
Sign Up to like & getrecommendations! Published in 2024 at "Small"
DOI: 10.1002/smll.202407100
Abstract: Exfoliation from quaternary hexagonal MAB (h-MAB) phases has been suggested as a method for producing 2D in-plane ordered MBenes (i-MBenes) with the general formula (M'2/3M″1/3)2AB2. However, experimental realization of defect-free i-MBenes has not been achieved… read more here.
Keywords: hexagonal mbene; discovery bimetallic; mbene; mbene mo2erb3t2 ... See more keywords
A Method for High‐Throughput Screening of Monoclonal Antibody Internalization Using a DNA/Protein Molecular Staple
Sign Up to like & getrecommendations! Published in 2025 at "Small Methods"
DOI: 10.1002/smtd.202401399
Abstract: The use of monoclonal antibodies (mAbs) as therapeutics or for targeted delivery to specific cells is reliant on understanding mAb‐receptor interactions. Of particular importance is the relationship between mAb binding and internalization into cells. Internalization… read more here.
Keywords: receptor; internalization; method high; binding internalization ... See more keywords
Purification of Human Monoclonal Antibodies and Their Fragments.
Sign Up to like & getrecommendations! Published in 2019 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-8958-4_7
Abstract: This chapter summarizes the most common chromatographic mAb and mAb fragment purification methods, starting by elucidating the relevant properties of the compounds and introducing the various chromatography modes that are available and useful for this… read more here.
Keywords: chromatography; mab; purity; purification human ... See more keywords
A broadly cross-reactive monoclonal antibody against hepatitis E virus capsid antigen
Sign Up to like & getrecommendations! Published in 2021 at "Applied Microbiology and Biotechnology"
DOI: 10.1007/s00253-021-11342-7
Abstract: Abstract To generate a hepatitis E virus (HEV) genotype 3 (HEV-3)–specific monoclonal antibody (mAb), the Escherichia coli–expressed carboxy-terminal part of its capsid protein was used to immunise BALB/c mice. The immunisation resulted in the induction… read more here.
Keywords: antibody; capsid protein; hev; capsid ... See more keywords
Altered binding avidities and improved growth inhibitory effects of novel anti-HER3 mAb against human cancers in the presence of HER1-or HER2-targeted drugs.
Sign Up to like & getrecommendations! Published in 2021 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2021.08.091
Abstract: HER1-and HER2-targeted drugs are effective in cancer therapy, especially against lung, breast and colon malignancies; however, resistance of cancer cells to HER1-and HER2-targeted therapies is becoming a serious problem. The avidity/affinity constant (KA) and growth… read more here.
Keywords: presence; her1; her1 her2; her2 ... See more keywords