Fcγ Receptor Activation by Human Monoclonal Antibody Aggregates.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of pharmaceutical sciences"
DOI: 10.1016/j.xphs.2019.10.046
Abstract: Protein aggregates are a potential risk factor for immunogenicity. The measurement, characterization, and control of protein aggregates in drug products are indispensable for the development of biopharmaceuticals, including therapeutic monoclonal antibodies (mAbs). In this study,… read more here.
Keywords: receptor activation; activation human; mab aggregates; activation ... See more keywords
Aggregation of Recombinant Monoclonal Antibodies and Its Role in Potential Immunogenicity.
Sign Up to like & getrecommendations! Published in 2018 at "Current pharmaceutical biotechnology"
DOI: 10.2174/1389201019666180605130252
Abstract: BACKGROUND Development of new recombinant biotechnology products has greatly expanded in the field of modern pharmacy and medicine. Since biological recombinant molecules are sensitive, simple or composed proteins, their function is heavily dependent on their… read more here.
Keywords: immunogenicity; monoclonal antibodies; structural variants; aggregation recombinant ... See more keywords