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   Articles with "maba" as a keyword



Discovery of the first Mycobacterium tuberculosis MabA (FabG1) inhibitors through a fragment-based screening.

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recommendations! Published in 2020 at "European journal of medicinal chemistry"

DOI: 10.1016/j.ejmech.2020.112440

Abstract: Mycobacterium tuberculosis (M.tb), the etiologic agent of tuberculosis, remains the leading cause of death from a single infectious agent worldwide. The emergence of drug-resistant M.tb strains stresses the need for drugs acting on new targets.… read more here.

Keywords: maba; tuberculosis; discovery first; maba fabg1 ... See more keywords

Discovery of Clinical Candidate CHF-6366: A Novel Super-soft Dual Pharmacology Muscarinic Antagonist and β2 Agonist (MABA) for the Inhaled Treatment of Respiratory Diseases.

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recommendations! Published in 2022 at "Journal of medicinal chemistry"

DOI: 10.1021/acs.jmedchem.2c00609

Abstract: The development of molecules embedding two distinct pharmacophores acting as muscarinic antagonists and β2 agonists (MABAs) promises to be an excellent opportunity to reduce formulation issues and boost efficacy through cross-talk and allosteric interactions. Herein,… read more here.

Keywords: clinical candidate; maba; pharmacology; chf 6366 ... See more keywords

Discovery, Multiparametric Optimization, and Solid-State Driven Identification of CHF-6550, a Novel Soft Dual Pharmacology Muscarinic Antagonist and β2 Agonist (MABA) for the Inhaled Treatment of Respiratory Diseases.

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recommendations! Published in 2024 at "Journal of medicinal chemistry"

DOI: 10.1021/acs.jmedchem.4c00298

Abstract: Clinical guidelines for COPD and asthma recommend inhaled β-adrenergic agonists, muscarinic antagonists, and, for frequent exacerbators, inhaled corticosteroids, with the challenge of combining them into a single device. The MABA (muscarinic antagonist and β2 agonist)… read more here.

Keywords: pharmacology; maba; solid state; chf 6550 ... See more keywords

CHF6366: characterisation of the bronchoprotective effect of a novel MABA compound in the experimental bronchospasm model in anaesthetised guinea pigs

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recommendations! Published in 2017 at "European Respiratory Journal"

DOI: 10.1183/1393003.congress-2017.oa4405

Abstract: The bronchoprotective effect of CHF6366, a novel dual antimuscarinic and β2 receptor-agonist (MABA) compound, was studied in a model of bronchospasm in anaesthetised guinea pigs that allows discrimination of the two pharmacological activities by using… read more here.

Keywords: maba; anaesthetised guinea; maba compound; effect ... See more keywords

Population genetic analysis of clinical Mycobacterium abscessus complex strains in China

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recommendations! Published in 2025 at "Frontiers in Cellular and Infection Microbiology"

DOI: 10.3389/fcimb.2024.1496896

Abstract: Background To explore the genetic characteristics of the Mycobacterium abscessus complex (MABC) population in China, given its rising clinical importance among nontuberculous mycobacteria. Methods We conducted population genetic analyses on 360 MABC genomes from China,… read more here.

Keywords: resistance; maba; abscessus; population ... See more keywords