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   Articles with "mabs" as a keyword



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CE methods for charge variant analysis of mAbs and complex format biotherapeutics

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recommendations! Published in 2024 at "ELECTROPHORESIS"

DOI: 10.1002/elps.202300170

Abstract: Charge heterogeneity analysis of monoclonal antibodies (mAbs) and complex formats, such as bispecifics, is crucial for therapeutic applications. In this study, we developed two capillary electrophoresis (CE)‐based methods, capillary zone electrophoresis (CZE) and imaged capillary… read more here.

Keywords: analysis; mabs; complex format; charge ... See more keywords

Therapeutic drug monitoring of monoclonal antibodies: Applicability based on their pharmacokinetic properties.

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recommendations! Published in 2019 at "Drug metabolism and pharmacokinetics"

DOI: 10.1016/j.dmpk.2018.11.003

Abstract: Monoclonal antibodies (mAbs) have dramatically improved clinical outcomes for inflammatory and malignant diseases. The elimination route of mAbs is cellular uptake by nonspecific pinocytosis or receptor-mediated endocytosis followed by proteolytic degradation which is protected by… read more here.

Keywords: monoclonal antibodies; mabs; drug; therapeutic drug ... See more keywords

Characterisation of monoclonal antibodies specific for hamster leukocyte differentiation molecules

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recommendations! Published in 2017 at "Veterinary Immunology and Immunopathology"

DOI: 10.1016/j.vetimm.2016.12.003

Abstract: Flow cytometry was used to identify mAbs that recognize conserved epitopes on hamster leukocyte differentiation molecules (hLDM) and also to characterize mAbs developed against hLDM. Initial screening of mAbs developed against LDMs in other species… read more here.

Keywords: differentiation molecules; leukocyte differentiation; mabs; hamster ... See more keywords

MarR-Dependent Transcriptional Regulation of mmpSL5 Induces Ethionamide Resistance in Mycobacterium abscessus

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recommendations! Published in 2022 at "Antimicrobial Agents and Chemotherapy"

DOI: 10.1128/aac.01350-22

Abstract: Mycobacterium abscessus (Mabs) is an emerging nontuberculosis mycobacterial (NTM) pathogen responsible for a wide variety of respiratory and cutaneous infections that are difficult to treat with standard antibacterial therapy. Mabs has a high degree of… read more here.

Keywords: mab 2648c; mabs; resistance; mycobacterium abscessus ... See more keywords

Heme alters biofilm formation in Mycobacterium abscessus

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recommendations! Published in 2024 at "Microbiology Spectrum"

DOI: 10.1128/spectrum.02415-24

Abstract: ABSTRACT Mycobacterium abscessus (Mabs) is commonly found in the cystic fibrosis (CF) lung. During infection, Mabs can form biofilms in the lung which reduce both the ability of the immune response to clear infection and… read more here.

Keywords: heme; mycobacterium abscessus; lung; mabs ... See more keywords

Mechanisms of action of monoclonal antibodies in oncology integrated in IMGT/mAb-DB

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recommendations! Published in 2023 at "Frontiers in Immunology"

DOI: 10.3389/fimmu.2023.1129323

Abstract: Background Cancer cells activate different immune checkpoint (IC) pathways in order to evade immunosurveillance. Immunotherapies involving ICs either block or stimulate these pathways and enhance the efficiency of the immune system to recognize and attack… read more here.

Keywords: oncology; mabs; mabs targeting; imgt mab ... See more keywords

Generation of novel human anti-OX-40 mAbs endowed with different biological properties as tools for cancer therapy

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recommendations! Published in 2025 at "Frontiers in Immunology"

DOI: 10.3389/fimmu.2025.1644391

Abstract: Introduction The second generation of Antibody-based Immunotherapy includes monoclonal antibodies against Immune Checkpoints (ICs), to modulate specific T cell responses against cancer or viruses. We recently generated a large repertoire of fully human antibodies targeting… read more here.

Keywords: cancer; immune cells; generation; culture ... See more keywords
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Isolation of Two Novel Human Anti-CTLA-4 mAbs with Intriguing Biological Properties on Tumor and NK Cells

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recommendations! Published in 2020 at "Cancers"

DOI: 10.3390/cancers12082204

Abstract: The cytotoxic T lymphocyte-antigen 4 (CTLA-4) has been considered an IC exclusively expressed on T cells, where it counteracts the co-stimulatory CD28 receptor, by competing for its binding to CD-80 and CD-86. We recently found… read more here.

Keywords: novel human; mabs; ctla; human mouse ... See more keywords

A Dual Strategy—In Vitro and In Silico—To Evaluate Human Antitetanus mAbs Addressing Their Potential Protective Action on TeNT Endocytosis in Primary Rat Neuronal Cells

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recommendations! Published in 2024 at "International Journal of Molecular Sciences"

DOI: 10.3390/ijms25115788

Abstract: Tetanus disease, caused by C. tetani, starts with wounds or mucous layer contact. Prevented by vaccination, the lack of booster shots throughout life requires prophylactic treatment in case of accidents. The incidence of tetanus is… read more here.

Keywords: tent; rat; mabs; tent endocytosis ... See more keywords