The newly identified MEK1 tyrosine phosphorylation target MACC1 is druggable by approved MEK1 inhibitors to restrict colorectal cancer metastasis
Sign Up to like & getrecommendations! Published in 2021 at "Oncogene"
DOI: 10.1038/s41388-021-01917-z
Abstract: Cancer metastasis causes >90% of cancer deaths and remains a major treatment challenge. Here we deciphered the impact of tyrosine phosphorylation of MACC1, a causative driver for cancer metastasis, for cancer cell signaling and novel… read more here.
Keywords: macc1; cancer metastasis; metastasis; cancer ... See more keywords
RETRACTED ARTICLE: LncRNA MACC1-AS1/MACC1 enhances the progression of glioma via regulating metabolic plasticity
Sign Up to like & getrecommendations! Published in 2020 at "Cell Cycle"
DOI: 10.1080/15384101.2020.1795595
Abstract: Statement of Retraction We, the Editors and Publisher of the journal Cell Cycle, have retracted the following article: Dahai Zheng, Daliang Che, Famu Lin, Xiang Wang, Lenian Lu, Jianmin Chen & Xiaobing Xu (2020) LncRNA… read more here.
Keywords: article; macc1; lncrna macc1; as1 macc1 ... See more keywords
MACC1 Correlates with Tumor Progression and Immune Cell Infiltration of Colon Adenocarcinoma and is Regulated by the lncRNA ZFAS1/miR-642a-5p Axis
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Oncology"
DOI: 10.1155/2022/8179208
Abstract: Colon adenocarcinoma (COAD) is the most common pathologic type of colon cancer. Metastasis is responsible for the high mortality rate of patients with COAD. The gene, metastasis-associated in colon cancer 1 (MACC1), is a biomarker… read more here.
Keywords: macc1; cell infiltration; immune cell; mir 642a ... See more keywords
Abstract 2000: Cancer metastasis driven by the novel MEK1 substrate MACC1 is restricted by clinically applicable MEK1 inhibitors
Sign Up to like & getrecommendations! Published in 2019 at "Tumor Biology"
DOI: 10.1158/1538-7445.am2019-2000
Abstract: Cancer metastasis is responsible for >90% of cancer deaths and remains a major treatment challenge. In search of new drivers of metastasis we identified the novel, previously undescribed gene Metastasis-Associated in Colon Cancer 1 (MACC1)… read more here.
Keywords: metastasis; cancer; mek1 inhibitors; macc1 ... See more keywords
MACC1 promotes angiogenesis in cholangiocarcinoma by upregulating VEGFA
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DOI: 10.2147/ott.s197319
Abstract: Purpose Angiogenesis actively contributes to tumor growth and metastasis. MACC1 was reported to be associated with tumor progression. In the present study, we aimed to investigate the expression and role of MACC1 in cholangiocarcinoma (CCA)… read more here.
Keywords: expression; macc1 knockdown; macc1 vegfa; macc1 ... See more keywords
MACC1 Is Associated With Epithelial–Mesenchymal Transition and Can Predict Poor Prognosis in Nasopharyngeal Carcinoma
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DOI: 10.3389/fonc.2021.644120
Abstract: Background Given the reported correlation between the oncogene metastasis-associated in colon cancer 1 (MACC1) and nasopharyngeal carcinoma (NPC), as well as between MACC1 and epithelial–mesenchymal transition (EMT), we speculated that EMT is a likely causative… read more here.
Keywords: mesenchymal transition; macc1; prognosis; epithelial mesenchymal ... See more keywords
Inhibition of MACC1-Induced Metastasis in Esophageal and Gastric Adenocarcinomas
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DOI: 10.3390/cancers14071773
Abstract: Simple Summary Esophageal and Gastric Adenocarcinomas (AGE/S) are characterized by early metastasis and poor survival. MACC1 (Metastasis Associated in Colon Cancer 1) acts in colon cancer as a metastasis inducer and is linked to reduced… read more here.
Keywords: gastric adenocarcinomas; metastasis; esophageal gastric; macc1 ... See more keywords
MicroRNA-598 Inhibits Cell Proliferation and Invasion of Glioblastoma by Directly Targeting Metastasis Associated in Colon Cancer-1 (MACC1).
Sign Up to like & getrecommendations! Published in 2018 at "Oncology research"
DOI: 10.3727/096504018x15185735627746
Abstract: The dysregulation of microRNA (miRNA) expression is closely related with tumorigenesis and tumor development in glioblastoma (GBM). In this study, we found that miRNA-598 (miR-598) expression was significantly downregulated in GBM tissues and cell lines.… read more here.
Keywords: mir 598; proliferation invasion; macc1; gbm ... See more keywords
Obesity, colorectal cancer and MACC1 expression: A possible novel molecular association
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Oncology"
DOI: 10.3892/ijo.2022.5307
Abstract: Obesity is a major and increasing public health concern, associated with an increased risk of and mortality from several types of cancer including colorectal cancer (CRC), being associated with cancer progression, metastasis and resistance to… read more here.
Keywords: macc1; cancer; obesity; study ... See more keywords
Alpha-fetoprotein can promote gastric cancer progression via upregulation of metastasis-associated colon cancer 1.
Sign Up to like & getrecommendations! Published in 2022 at "Oncology letters"
DOI: 10.3892/ol.2022.13204
Abstract: High serum alpha-fetoprotein (AFP) level is a predictor of poor prognosis in patients with gastric cancer (GC). AFP-producing GC (AFP-GC) is an aggressive subtype of GC characterized by a high incidence of liver metastasis and… read more here.
Keywords: metastasis; macc1; progression; expression ... See more keywords