Impact of Portable Normothermic Blood-Based Machine Perfusion on Outcomes of Liver Transplant
Sign Up to like & getrecommendations! Published in 2022 at "JAMA Surgery"
DOI: 10.1001/jamasurg.2021.6781
Abstract: Key Points Question Can oxygenated portable normothermic perfusion of deceased donor livers for transplant improve outcomes compared with the current standard of care using ischemic cold storage? Findings In this multicenter randomized clinical trial of… read more here.
Keywords: portable normothermic; outcomes liver; liver transplant; machine perfusion ... See more keywords
Letter to Editor: Repair or Prevent: What Is the Real Impact of Normothermic Machine Perfusion in Liver Transplantation?
Sign Up to like & getrecommendations! Published in 2019 at "Hepatology"
DOI: 10.1002/hep.30567
Abstract: We read with great interest the paper by Jassem et al(1), which provides detailed gene expression profiles of human livers during normothermic machine perfusion (NMP), compared to conventional cold storage. Authors should be congratulated to… read more here.
Keywords: machine perfusion; letter editor; editor repair; normothermic machine ... See more keywords
A Call for Randomization in Clinical Trials of Liver Machine Perfusion Preservation
Sign Up to like & getrecommendations! Published in 2020 at "Hepatology"
DOI: 10.1002/hep.31686
Abstract: Liver transplantation is a lifesaving operation for patients with advanced liver failure. Although mortality from liver disease continues to increase, the number of available grafts remain relatively unchanged, leading to the death of about 15-30%… read more here.
Keywords: liver machine; call randomization; trials liver; clinical trials ... See more keywords
Machine perfusion in liver transplantation
Sign Up to like & getrecommendations! Published in 2022 at "Hepatology"
DOI: 10.1002/hep.32546
Abstract: Although liver transplantation is a true success story, many patients still die awaiting an organ. The increasing need for liver grafts therefore remains an unsolved challenge to the transplant community. To address this, transplant donor… read more here.
Keywords: machine perfusion; perfusion; liver; liver transplantation ... See more keywords
Liver ex situ machine perfusion preservation: A review of the methodology and results of large animal studies and clinical trials
Sign Up to like & getrecommendations! Published in 2017 at "Liver Transplantation"
DOI: 10.1002/lt.24751
Abstract: Ex vivo machine perfusion (MP) is a promising way to better preserve livers prior to transplantation. Currently, no methodology has a verified benefit over simple cold storage. Before becoming clinically feasible, MP requires validation in… read more here.
Keywords: methodology; perfusion; preservation; clinical trials ... See more keywords
Combined Hypothermic and Normothermic Machine Perfusion Improves Functional Recovery of Extended Criteria Donor Livers
Sign Up to like & getrecommendations! Published in 2018 at "Liver Transplantation"
DOI: 10.1002/lt.25315
Abstract: Hypothermic oxygenated perfusion (HOPE) and normothermic perfusion are seen as distinct techniques of ex situ machine perfusion of the liver. We aimed to demonstrate the feasibility of combining both techniques and whether it would improve… read more here.
Keywords: recovery; perfusion; donor livers; machine perfusion ... See more keywords
Manipulation of Lipid Metabolism During Normothermic Machine Perfusion: Effect of Defatting Therapies on Donor Liver Functional Recovery
Sign Up to like & getrecommendations! Published in 2019 at "Liver Transplantation"
DOI: 10.1002/lt.25439
Abstract: Strategies to increase the use of steatotic donor livers are required to tackle the mortality on the transplant waiting list. We aimed to test the efficacy of pharmacological enhancement of the lipid metabolism of human… read more here.
Keywords: metabolism; normothermic machine; functional recovery; machine perfusion ... See more keywords
Normothermic Machine Perfusion in Liver Transplantation: Feasibility and Promise of Avoiding Recooling Before Engrafting
Sign Up to like & getrecommendations! Published in 2019 at "Liver Transplantation"
DOI: 10.1002/lt.25473
Abstract: It is well known that ischemia and the reperfusion process are distinct nonimmunological events that negatively impact graft outcome and induce delayed graft function, which are associated with high rates of organ failure, retransplantation, and… read more here.
Keywords: normothermic machine; transplantation feasibility; transplantation; liver transplantation ... See more keywords
The Current Landscape of Liver Transplantation After Ex Situ Machine Perfusion and Normothermic Regional Perfusion in the United States
Sign Up to like & getrecommendations! Published in 2022 at "Liver Transplantation"
DOI: 10.1002/lt.26404
Abstract: In the United States, there remains a discrepancy between the number of liver transplantation (LT) candidates awaiting transplantation and the availability of donor organs. To help address this discrepancy, the transplantation community has continued to… read more here.
Keywords: machine perfusion; transplantation; perfusion; situ machine ... See more keywords
Cerium oxide nanoparticles administration during machine perfusion of discarded human livers: A pilot study
Sign Up to like & getrecommendations! Published in 2022 at "Liver Transplantation"
DOI: 10.1002/lt.26421
Abstract: The combined approach of ex situ normothermic machine perfusion (NMP) and nanotechnology represents a strategy to mitigate ischemia/reperfusion injury in liver transplantation (LT). We evaluated the uptake, distribution, and efficacy of antioxidant cerium oxide nanoparticles… read more here.
Keywords: machine perfusion; discarded human; perfusion; oxide nanoparticles ... See more keywords
Current review of machine perfusion in liver transplantation from the Japanese perspective
Sign Up to like & getrecommendations! Published in 2021 at "Surgery Today"
DOI: 10.1007/s00595-021-02265-x
Abstract: In light of the present evidence, machine perfusion is opening up new horizons in the field of liver transplantation. Although many advances have been made in liver transplantation, organ preservation methods have so far changed… read more here.
Keywords: normothermic machine; machine perfusion; liver transplantation; perfusion ... See more keywords