Discovery of the Biosynthetic Machinery for the Stravidins, Biotin Antimetabolites.
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DOI: 10.1021/acschembio.9b00890
Abstract: Stravidins are peptide antibiotics produced by Streptomyces spp. Their antibacterial activity derives from an unusual amiclenomycin monomer, the warhead that inhibits biotin biosynthesis. Despite being discovered over five decades ago, stravidin biosynthesis has remained a… read more here.
Keywords: machinery; biosynthetic machinery; biotin antimetabolites; stravidins biotin ... See more keywords