An attenuated Machupo virus with a disrupted L-segment intergenic region protects guinea pigs against lethal Guanarito virus infection
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-04889-x
Abstract: Machupo virus (MACV) is a New World (NW) arenavirus and causative agent of Bolivian hemorrhagic fever (HF). Here, we identified a variant of MACV strain Carvallo termed Car91 that was attenuated in guinea pigs. Infection… read more here.
Keywords: guinea pigs; segment; infection; virus ... See more keywords
Isolation of Reconstructed Functional Ribonucleoprotein Complexes of Machupo Virus
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DOI: 10.1128/jvi.01054-21
Abstract: Arenaviruses are rodent-borne pathogens that can cause severe disease in humans. All arenaviruses begin the infection cycle with delivery of the virus replication machinery into the cytoplasm of the host cell. ABSTRACT Arenaviruses initiate infection… read more here.
Keywords: machupo virus; ribonucleoprotein; replication; machinery ... See more keywords
Monoclonal Antibodies with Neutralizing Activity and Fc-Effector Functions against the Machupo Virus Glycoprotein
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Virology"
DOI: 10.1128/jvi.01741-19
Abstract: MACV infections are a significant public health concern and lead to high case fatality rates. No specific treatment or vaccine for MACV infections exist. However, cases of Junin virus infection, a related virus, can be… read more here.
Keywords: machupo virus; activity; macv could; virus ... See more keywords