NMR study of non-structural proteins–part III: 1H, 13C, 15N backbone and side-chain resonance assignment of macro domain from Chikungunya virus (CHIKV)
Sign Up to like & getrecommendations! Published in 2018 at "Biomolecular NMR Assignments"
DOI: 10.1007/s12104-017-9775-2
Abstract: Macro domains are conserved protein domains found in eukaryotic organisms, bacteria, and archaea as well as in certain viruses. They consist of 130–190 amino acids and can bind ADP-ribose. Although the exact role of these… read more here.
Keywords: chikv; non structural; macro domain; macro ... See more keywords
Conformational plasticity of the VEEV macro domain is important for binding of ADP-ribose
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Structural Biology"
DOI: 10.1016/j.jsb.2019.02.008
Abstract: Abstract Venezuelan equine encephalitis virus (VEEV) is a new world alphavirus which can be involved in several central nervous system disorders such as encephalitis and meningitis. The VEEV genome codes for 4 non-structural proteins (nsP),… read more here.
Keywords: binding adp; macro domain; veev; macro ... See more keywords
Mechanistic Insights into Autoinhibition of the Oncogenic Chromatin Remodeler ALC1
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DOI: 10.1016/j.molcel.2017.10.017
Abstract: Summary Human ALC1 is an oncogene-encoded chromatin-remodeling enzyme required for DNA repair that possesses a poly(ADP-ribose) (PAR)-binding macro domain. Its engagement with PARylated PARP1 activates ALC1 at sites of DNA damage, but the underlying mechanism… read more here.
Keywords: dna damage; alc1; macro domain;
Structural, Biophysical, and Biochemical Elucidation of the SARS-CoV-2 Nonstructural Protein 3 Macro Domain
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DOI: 10.1021/acsinfecdis.0c00441
Abstract: The pandemic outbreak of a novel coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has threatened the global public health and economy since late December 2019. SARS-CoV-2 encodes the conserved macro domain within nonstructural protein… read more here.
Keywords: sars cov; nonstructural protein; structural biophysical; macro domain ... See more keywords
Biochemical and Morphological Characterization of a Neurodevelopmental Disorder-Related Mono-ADP-Ribosylhydrolase, MACRO Domain Containing 2
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DOI: 10.1159/000492271
Abstract: MACRO Domain Containing 2 (MacroD2) is a neurodevelopmental disorder-related mono-ADP-ribosylhydrolase. Molecular features of this protein in neural tissues are largely unknown. In this study, we generated a specific antibody against MacroD2, and carried out expression… read more here.
Keywords: domain containing; related mono; disorder related; macro domain ... See more keywords