Perphenazine-Macrocycle Conjugates Rapidly Sequester the Aβ42 Monomer and Prevent Formation of Toxic Oligomers and Amyloid.
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DOI: 10.1021/acschemneuro.2c00498
Abstract: Alzheimer's disease is imposing a growing social and economic burden worldwide, and effective therapies are urgently required. One possible approach to modulation of the disease outcome is to use small molecules to limit the conversion… read more here.
Keywords: conjugates rapidly; macrocycle conjugates; perphenazine macrocycle; toxic oligomers ... See more keywords