Automated Design of Macrocycles for Therapeutic Applications: From Small Molecules to Peptides and Proteins.
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DOI: 10.1021/acs.jmedchem.0c01500
Abstract: Macrocycles and cyclic peptides are increasingly attractive therapeutic modalities as they often have improved affinity, are able to bind to extended protein surfaces, and otherwise have favorable properties. Macrocyclization of a known binder may stabilize… read more here.
Keywords: molecules peptides; automated design; therapeutic applications; macrocycles therapeutic ... See more keywords