Abstract 5331: DNA-encoded macrocyclic compound libraries for challenging targets
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DOI: 10.1158/1538-7445.am2023-5331
Abstract: Increasingly drug discovery programs require the development of orally available and cell permeable classes of drugs derived from the chemical space beyond Lipinski’s rule of 5 (bRO5). The chameleon-like physicochemical properties and differentiated binding modes… read more here.
Keywords: compound libraries; macrocyclic compound; dna; dna encoded ... See more keywords