Synthesis of 12- to 26-Membered Macrocyclic Dienes by Directed Intramolecular Alkene/Alkyne Cross-Coupling.
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DOI: 10.1021/acs.orglett.5c01106
Abstract: The first iridium-catalyzed intramolecular alkene/alkyne cross-coupling reaction has been developed to prepare a wide range of 12- to 26-membered macrocyclic 1,3-dienes. This operationally simple protocol proceeded by NHTs amide-enabled alkenyl C-H functionalization and exhibited wide… read more here.
Keywords: alkene alkyne; macrocyclic dienes; cross coupling; intramolecular alkene ... See more keywords