Macrocyclic Immunoproteasome Inhibitors as a Potential Therapy for Alzheimer's Disease.
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DOI: 10.1021/acs.jmedchem.1c00291
Abstract: Previously, we reported that immunoproteasome (iP)-targeting linear peptide epoxyketones improve cognitive function in mouse models of Alzheimer's disease (AD) in a manner independent of amyloid β. However, these compounds' clinical prospect for AD is limited… read more here.
Keywords: immunoproteasome inhibitors; alzheimer disease; disease; inhibitors potential ... See more keywords